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ENZYME entry: EC 1.17.99.3
Accepted Name |
3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanoyl-CoA 24-hydroxylase.
|
Alternative Name(s) |
3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oate 24-hydroxylase. |
3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanoyl-CoA oxidase. |
THCA-CoA oxidase. |
THC-CoA oxidase. |
trihydroxycoprostanoyl-CoA oxidase. |
Reaction catalysed |
(25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oyl-CoA + A + H2O <=> (24R,25R)-3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestan-26-oyl-CoA + AH2 |
Comment(s) |
- Requires ATP.
- The reaction in mammals possibly involves dehydrogenation to give a
24(25)-double bond followed by hydration.
- However, in amphibians such as the Oriental fire-bellied toad
(Bombina orientalis), it is probable that the product is formed via
direct hydroxylation of the saturated side chain of (25R)-
3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oate and not via
hydration of a 24(25) double bond.
- In microsomes, the free acid is preferred to the coenzyme A ester,
whereas in mitochondria, the coenzyme A ester is preferred to the
free-acid form of the substrate.
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Cross-references |
BRENDA | 1.17.99.3 |
EC2PDB | 1.17.99.3 |
ExplorEnz | 1.17.99.3 |
PRIAM enzyme-specific profiles | 1.17.99.3 |
KEGG Ligand Database for Enzyme Nomenclature | 1.17.99.3 |
IUBMB Enzyme Nomenclature | 1.17.99.3 |
IntEnz | 1.17.99.3 |
MEDLINE | Find literature relating to 1.17.99.3 |
MetaCyc | 1.17.99.3 |
Rhea expert-curated reactions | 1.17.99.3 |
UniProtKB/Swiss-Prot |
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