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ENZYME entry: EC 1.17.99.4

Accepted Name
uracil/thymine dehydrogenase.
Alternative Name(s)
uracil dehydrogenase.
uracil oxidase.
uracil-thymine oxidase.
Reaction catalysed
  • A + H2O + uracil <=> AH2 + barbiturate + H(+)
  • A + H2O + thymine <=> 5-methylbarbiturate + AH2 + H(+)
Comment(s)
  • Forms part of the oxidative pyrimidine-degrading pathway in some microorganisms, along with EC 3.5.2.1 and EC 3.5.1.95.
  • Mammals, plants and other microorganisms utilize the reductive pathway, comprising EC 1.3.1.1 or EC 1.3.1.2, EC 3.5.2.2 and EC 3.5.1.6, with the ultimate degradation products being an L-amino acid, NH3 and CO2.
  • Formerly EC 1.1.99.19 and EC 1.2.99.1.
Cross-references
BRENDA1.17.99.4
EC2PDB1.17.99.4
ExplorEnz1.17.99.4
PRIAM enzyme-specific profiles1.17.99.4
KEGG Ligand Database for Enzyme Nomenclature1.17.99.4
IUBMB Enzyme Nomenclature1.17.99.4
IntEnz1.17.99.4
MEDLINEFind literature relating to 1.17.99.4
MetaCyc1.17.99.4
Rhea expert-curated reactions1.17.99.4

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.17.99.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.17.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.-.-.-