ENZYME entry: EC 1.17.99.4
| Accepted Name |
|---|
| Uracil/thymine dehydrogenase.
|
| Alternative Name(s) |
|---|
| Uracil dehydrogenase. |
| Uracil oxidase. |
| Uracil-thymine oxidase. |
| Reaction catalysed |
|---|
- Uracil + H(2)O + acceptor <=> barbiturate + reduced acceptor
- Thymine + H(2)O + acceptor <=> 5-methylbarbiturate + reduced acceptor
|
| Comment(s) |
|---|
- Forms part of the oxidative pyrimidine-degrading pathway in some
microorganisms, along with EC 3.5.2.1 and EC 3.5.1.95.
- Mammals, plants and other microorganisms utilize the reductive
pathway, comprising EC 1.3.1.1 or EC 1.3.1.2, EC 3.5.2.2 and
EC 3.5.1.6, with the ultimate degradation products being an L-amino
acid, NH(3) and CO(2).
- Formerly EC 1.1.99.19 and EC 1.2.99.1.
|
| Cross-references |
|---|
| BRENDA | 1.17.99.4 |
| EC2PDB | 1.17.99.4 |
| ExplorEnz | 1.17.99.4 |
| PRIAM enzyme-specific profiles | 1.17.99.4 |
| KEGG Ligand Database for Enzyme Nomenclature | 1.17.99.4 |
| IUBMB Enzyme Nomenclature | 1.17.99.4 |
| IntEnz | 1.17.99.4 |
| MEDLINE | Find literature relating to 1.17.99.4 |
| MetaCyc | 1.17.99.4 |
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