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ENZYME entry: EC 3.5.2.1

Accepted Name
Barbiturase.
Reaction catalysed
Barbiturate + H(2)O <=> 3-oxo-3-ureidopropanoate
Cofactor(s)
Zn(2+).
Comment(s)
  • Specific for barbiturate as substrate.
  • Forms part of the oxidative pyrimidine-degrading pathway in some microorganisms, along with EC 1.17.99.4 and EC 3.5.1.95.
  • It was previously thought that the end-products of the reaction were malonate and urea.
  • May be involved in the regulation of pyrimidine metabolism, along with EC 2.4.2.9.
Cross-references
BRENDA3.5.2.1
EC2PDB3.5.2.1
ExplorEnz3.5.2.1
PRIAM enzyme-specific profiles3.5.2.1
KEGG Ligand Database for Enzyme Nomenclature3.5.2.1
IUBMB Enzyme Nomenclature3.5.2.1
IntEnz3.5.2.1
MEDLINEFind literature relating to 3.5.2.1
MetaCyc3.5.2.1
Rhea expert-curated reactions3.5.2.1
UniProtKB/Swiss-Prot
A1SGT4, BAH1_NOCSJ;  A1SPN2, BAH2_NOCSJ;  Q8RSQ2, BAH_RHOER;  

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