ENZYME

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A new class EC 7, Translocases, has been added to the EC list. It will be part of ENZYME from release 2018_10. Read more about EC 7 here.

ENZYME entry: EC 1.18.6.2

Accepted Name
Vanadium-dependent nitrogenase.
Reaction catalysed
12 reduced ferredoxin + 12 H(+) + N(2) + 40 ATP + 40 H(2)O <=> 12 oxidized ferredoxin + 3 H(2) + 2 NH(3) + 40 ADP + 40 phosphate
Cofactor(s)
Mg(2+).
Comment(s)
This enzyme, originally isolated from the bacterium Azotobacter vinelandii, is a complex of two components (namely dinitrogen reductase and dinitrogenase). Dinitrogen reductase is a [4Fe-4S] protein, which, in the presence of ATP, transfers an electron from ferredoxin to the dinitrogenase component. Dinitrogenase is a vanadium-iron protein that reduces dinitrogen to two molecules of ammonia in three successive two-electron reductions via diazine and hydrazine. Compared with EC 1.18.6.1, this enzyme produces more dihydrogen and consumes more ATP per dinitrogen molecule being reduced. Unlike EC 1.18.6.1, this enzyme can also use CO as substrate, producing ethylene, ethane and propane.
Cross-references
BRENDA	1.18.6.2
EC2PDB	1.18.6.2
ExplorEnz	1.18.6.2
PRIAM enzyme-specific profiles	1.18.6.2
KEGG Ligand Database for Enzyme Nomenclature	1.18.6.2
IUBMB Enzyme Nomenclature	1.18.6.2
IntEnz	1.18.6.2
MEDLINE	Find literature relating to 1.18.6.2
MetaCyc	1.18.6.2