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ENZYME entry: EC 1.18.6.2

Accepted Name
Vanadium-dependent nitrogenase.
Reaction catalysed
12 reduced ferredoxin + 12 H(+) + N(2) + 40 ATP + 40 H(2)O <=> 12 oxidized ferredoxin + 3 H(2) + 2 NH(3) + 40 ADP + 40 phosphate
Cofactor(s)
Mg(2+).
Comment(s)
  • This enzyme, originally isolated from the bacterium Azotobacter vinelandii, is a complex of two components (namely dinitrogen reductase and dinitrogenase).
  • Dinitrogen reductase is a [4Fe-4S] protein, which, in the presence of ATP, transfers an electron from ferredoxin to the dinitrogenase component.
  • Dinitrogenase is a vanadium-iron protein that reduces dinitrogen to two molecules of ammonia in three successive two-electron reductions via diazine and hydrazine.
  • Compared with EC 1.18.6.1, this enzyme produces more dihydrogen and consumes more ATP per dinitrogen molecule being reduced.
  • Unlike EC 1.18.6.1, this enzyme can also use CO as substrate, producing ethylene, ethane and propane.
Cross-references
BRENDA1.18.6.2
EC2PDB1.18.6.2
ExplorEnz1.18.6.2
PRIAM enzyme-specific profiles1.18.6.2
KEGG Ligand Database for Enzyme Nomenclature1.18.6.2
IUBMB Enzyme Nomenclature1.18.6.2
IntEnz1.18.6.2
MEDLINEFind literature relating to 1.18.6.2
MetaCyc1.18.6.2

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.18.6.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.18.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.-.-.-