| Accepted Name |
|---|
| nitrogenase (flavodoxin)
|
| Reaction catalysed |
|---|
| 16 ATP + 16 H2O + N2 + 4 reduced [flavodoxin] <=> 16 ADP + 18 H(+) + H2 + 2 NH4(+) + 4 oxidized [flavodoxin] + 16 phosphate |
| Comment(s) |
|---|
- Composed of two components, dinitrogen reductase and dinitrogenase,
that can be separated but are both required for nitrogenase activity.
- Dinitrogen reductase is a [4Fe-4S] protein, which, at the expense of
ATP, transfers electrons from a dedicated flavodoxin to
dinitrogenase.
- Dinitrogenase is a protein complex that contains either a molybdenum-
iron cofactor, a vanadium-iron cofactor, or an iron-iron cofactor,
that reduces dinitrogen in three succesive two-electron reductions
from nitrogen to diimine to hydrazine to two molecules of ammonia.
- The reduction is initiated by formation of hydrogen.
- The enzyme can also reduce acetylene to ethylene (but only very
slowly to ethane), azide to nitrogen and ammonia, and cyanide to
methane and ammonia.
- In the absence of a suitable substrate, hydrogen is slowly formed.
- Some enzymes utilize ferredoxin rather than flavodoxin as the
electron donor (see EC 1.18.6.1).
|
| Cross-references |
|---|
| BRENDA | 1.19.6.1 |
| EC2PDB | 1.19.6.1 |
| ExplorEnz | 1.19.6.1 |
| PRIAM enzyme-specific profiles | 1.19.6.1 |
| KEGG Ligand Database for Enzyme Nomenclature | 1.19.6.1 |
| IUBMB Enzyme Nomenclature | 1.19.6.1 |
| IntEnz | 1.19.6.1 |
| MEDLINE | Find literature relating to 1.19.6.1 |
| MetaCyc | 1.19.6.1 |
| Rhea expert-curated reactions | 1.19.6.1 |
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