ENZYME entry: EC 220.127.116.11
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|16 ATP + 16 H2O + N2 + 4 reduced [flavodoxin] <=> 16 ADP + 18 H(+) + H2 + 2 NH4(+) + 4 oxidized [flavodoxin] + 16 phosphate|
- Composed of two components, dinitrogen reductase and dinitrogenase,
that can be separated but are both required for nitrogenase activity.
- Dinitrogen reductase is a [4Fe-4S] protein, which, at the expense of
ATP, transfers electrons from a dedicated flavodoxin to
- Dinitrogenase is a protein complex that contains either a molybdenum-
iron cofactor, a vanadium-iron cofactor, or an iron-iron cofactor,
that reduces dinitrogen in three succesive two-electron reductions
from nitrogen to diimine to hydrazine to two molecules of ammonia.
- The reduction is initiated by formation of hydrogen.
- The enzyme can also reduce acetylene to ethylene (but only very
slowly to ethane), azide to nitrogen and ammonia, and cyanide to
methane and ammonia.
- In the absence of a suitable substrate, hydrogen is slowly formed.
- Some enzymes utilize ferredoxin rather than flavodoxin as the
electron donor (see EC 18.104.22.168).
|PRIAM enzyme-specific profiles||22.214.171.124|
|KEGG Ligand Database for Enzyme Nomenclature||126.96.36.199|
|IUBMB Enzyme Nomenclature||188.8.131.52|
|MEDLINE||Find literature relating to 184.108.40.206|
|Rhea expert-curated reactions||220.127.116.11|
entries corresponding to 1.19.6.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.19.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.-.-.-