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ENZYME entry: EC 1.2.1.101

Accepted Name
L-tyrosine reductase.
Reaction catalysed
L-tyrosinal + NADP(+) + AMP + diphosphate <=> L-tyrosine + NADPH + ATP
Comment(s)
  • The enzyme, characterized from the ascomycete fungus Aspergillus flavus, is specific for L-tyrosine.
  • It contains three domains - an adenylation domain, a peptidyl-carrier protein (PCP) domain, and a reductase domain, and requires activation by attachment of a phosphopantetheinyl group.
  • The enzyme activates its substrate to an adenylate form, followed by a transfer to the PCP domain.
  • The resulting thioester is subsequently transferred to the reductase domain, where it is reduced to the aldehyde.
Cross-references
BRENDA1.2.1.101
EC2PDB1.2.1.101
ExplorEnz1.2.1.101
PRIAM enzyme-specific profiles1.2.1.101
KEGG Ligand Database for Enzyme Nomenclature1.2.1.101
IUBMB Enzyme Nomenclature1.2.1.101
IntEnz1.2.1.101
MEDLINEFind literature relating to 1.2.1.101
MetaCyc1.2.1.101
Rhea expert-curated reactions1.2.1.101

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.2.1.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.2.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.-.-.-