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ENZYME entry: EC 1.2.1.107

Accepted Name
Glyceraldehyde-3-phosphate dehydrogenase (arsenate-transferring).
Reaction catalysed
D-glyceraldehyde 3-phosphate + arsenate + NAD(+) <=> 1-arsono-3-phospho-D-glycerate + NADH
Comment(s)
  • The enzyme, discovered in bacteria, is very similar to EC 1.2.1.12.
  • However, the gene encoding it is located in arsenic resistance islands in the chromosome, next to a gene (arsJ) that encodes a transporter that removes the product, 1-arsono-3-phosphoglycerate, from the cell.
  • Together the two proteins form an arsenic detoxification system.
Cross-references
BRENDA1.2.1.107
EC2PDB1.2.1.107
ExplorEnz1.2.1.107
PRIAM enzyme-specific profiles1.2.1.107
KEGG Ligand Database for Enzyme Nomenclature1.2.1.107
IUBMB Enzyme Nomenclature1.2.1.107
IntEnz1.2.1.107
MEDLINEFind literature relating to 1.2.1.107
MetaCyc1.2.1.107
Rhea expert-curated reactions1.2.1.107

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.2.1.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.2.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.-.-.-