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ENZYME

ENZYME entry: EC 1.2.1.30

Accepted Name
carboxylate reductase (NADP(+))
Alternative Name(s)
aryl-aldehyde dehydrogenase (NADP(+))
Reaction catalysed
AMP + an aromatic aldehyde + diphosphate + NADP(+) = an aromatic carboxylate + ATP + H(+) + NADPH
Comment(s)
  • The enzyme contains an adenylation domain, a phosphopantetheinyl binding domain, and a reductase domain, and requires activation by attachment of a phosphopantetheinyl group.
  • The enzyme activates its substrate to an adenylate form, followed by a transfer to the phosphopantetheinyl binding domain.
  • The resulting thioester is subsequently transferred to the reductase domain, where it is reduced to an aldehyde and released.
Cross-references
BRENDA1.2.1.30
EC2PDB1.2.1.30
ExplorEnz1.2.1.30
PRIAM enzyme-specific profiles1.2.1.30
KEGG Ligand Database for Enzyme Nomenclature1.2.1.30
IUBMB Enzyme Nomenclature1.2.1.30
IntEnz1.2.1.30
MEDLINEFind literature relating to 1.2.1.30
MetaCyc1.2.1.30
Rhea expert-curated reactions1.2.1.30
UniProtKB/Swiss-Prot
Q7RW48, CAR_NEUCRQ6RKB1, CAR_NOCIO

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