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ENZYME entry: EC 1.2.1.59

Accepted Name
glyceraldehyde-3-phosphate dehydrogenase (NAD(P)(+)) (phosphorylating).
Alternative Name(s)
NAD(P)-dependent glyceraldehyde-3-phosphate dehydrogenase.
triosephosphate dehydrogenase (NAD(P)(+)).
triosephosphate dehydrogenase (NAD(P)).
Reaction catalysed
  • D-glyceraldehyde 3-phosphate + NADP(+) + phosphate <=> (2R)-3-phospho-glyceroyl phosphate + H(+) + NADPH
  • D-glyceraldehyde 3-phosphate + NAD(+) + phosphate <=> (2R)-3-phospho-glyceroyl phosphate + H(+) + NADH
Comment(s)
NAD(+) and NADP(+) can be used as cofactors with similar efficiency, unlike EC 1.2.1.12 and EC 1.2.1.13, which are NAD(+)- and NADP(+)- dependent, respectively.
Cross-references
BRENDA1.2.1.59
EC2PDB1.2.1.59
ExplorEnz1.2.1.59
PRIAM enzyme-specific profiles1.2.1.59
KEGG Ligand Database for Enzyme Nomenclature1.2.1.59
IUBMB Enzyme Nomenclature1.2.1.59
IntEnz1.2.1.59
MEDLINEFind literature relating to 1.2.1.59
MetaCyc1.2.1.59
Rhea expert-curated reactions1.2.1.59
UniProtKB/Swiss-Prot
P58837, G3P1_METAC;  Q46AH5, G3P1_METBF;  O34425, G3P2_BACSU;  
P58838, G3P2_METAC;  Q465K9, G3P2_METBF;  P58554, G3P2_NOSS1;  
P80505, G3P2_SYNY3;  P34917, G3P2_TRIV2;  O09452, G3PA_GUITH;  
Q9YFS9, G3P_AERPE;  O28542, G3P_ARCFU;  Q5V061, G3P_HALMA;  
B0R2M2, G3P_HALS3;  Q9HSS7, G3P_HALSA;  Q48335, G3P_HALVA;  
A2BLC6, G3P_HYPBU;  A6UUN9, G3P_META3;  A7IB57, G3P_METB6;  
P19314, G3P_METBR;  Q12XM4, G3P_METBU;  P10618, G3P_METFE;  
P19315, G3P_METFO;  Q2FNA2, G3P_METHJ;  Q58546, G3P_METJA;  
P58839, G3P_METKA;  A4FZL2, G3P_METM5;  A9A6M9, G3P_METM6;  
A6VIW4, G3P_METM7;  Q8PTD3, G3P_METMA;  A3CYG8, G3P_METMJ;  
Q6M0E6, G3P_METMP;  A5ULT9, G3P_METS3;  A4YHA5, G3P_METS5;  
Q2NEN0, G3P_METST;  O27090, G3P_METTH;  A6URW1, G3P_METVS;  
Q3IUT3, G3P_NATPD;  Q6L125, G3P_PICTO;  Q9V1P1, G3P_PYRAB;  
Q8ZWK7, G3P_PYRAE;  A4WIW2, G3P_PYRAR;  A3MTU1, G3P_PYRCJ;  
P61879, G3P_PYRFU;  O59494, G3P_PYRHO;  A1RV79, G3P_PYRIL;  
B1YD06, G3P_PYRNV;  P61880, G3P_PYRWO;  P39460, G3P_SACS2;  
Q4J940, G3P_SULAC;  C3N6F0, G3P_SULIA;  C4KHW5, G3P_SULIK;  
C3MQN0, G3P_SULIL;  C3MWN0, G3P_SULIM;  C3NGT6, G3P_SULIN;  
C3NEV8, G3P_SULIY;  Q971K2, G3P_SULTO;  Q9HJ69, G3P_THEAC;  
Q5JHB5, G3P_THEKO;  B6YUU0, G3P_THEON;  C6A312, G3P_THESM;  
Q97BJ8, G3P_THEVO;  

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