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A new class EC 7, Translocases, has been added to the EC list. It will be part of ENZYME from release 2018_10. Read more about EC 7 here.

ENZYME entry: EC

Accepted Name
Pyruvate oxidase.
Alternative Name(s)
Phosphate-dependent pyruvate oxidase.
Pyruvic oxidase.
Reaction catalysed
Pyruvate + phosphate + O(2) <=> acetyl phosphate + CO(2) + H(2)O(2)
FAD; Thiamine diphosphate.
  • Two reducing equivalents are transferred from the resonant carbanion/enamine forms of 2-hydroxyethyl-thiamine-diphosphate to the adjacent flavin cofactor, yielding 2-acetyl-thiamine diphosphate (AcThDP) and reduced flavin.
  • FADH is reoxidized by O(2) to yield H(2)O(2) and FAD and AcThDP is cleaved phosphorolytically to acetyl phosphate and thiamine diphosphate.
PRIAM enzyme-specific profiles1.2.3.3
KEGG Ligand Database for Enzyme Nomenclature1.2.3.3
IUBMB Enzyme Nomenclature1.2.3.3
MEDLINEFind literature relating to
P37063, POXB_LACPL;  Q54970, POXB_STRPN;  

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All UniProtKB/Swiss-Prot entries referenced in this entry, with possibility to download in different formats, align etc.
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.2.3.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.2.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.-.-.-