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ENZYME

ENZYME entry: EC 1.2.3.3

Accepted Name
pyruvate oxidase
Alternative Name(s)
phosphate-dependent pyruvate oxidase
pyruvic oxidase
Reaction catalysed
H(+) + O2 + phosphate + pyruvate = acetyl phosphate + CO2 + H2O2
Comment(s)
  • Two reducing equivalents are transferred from the resonant carbanion/enamine forms of 2-hydroxyethyl-thiamine-diphosphate to the adjacent flavin cofactor, yielding 2-acetyl-thiamine diphosphate (AcThDP) and reduced flavin.
  • FADH is reoxidized by O2 to yield H2O2 and FAD and AcThDP is cleaved phosphorolytically to acetyl phosphate and thiamine diphosphate.
Cross-references
BRENDA1.2.3.3
EC2PDB1.2.3.3
ExplorEnz1.2.3.3
PRIAM enzyme-specific profiles1.2.3.3
KEGG Ligand Database for Enzyme Nomenclature1.2.3.3
IUBMB Enzyme Nomenclature1.2.3.3
IntEnz1.2.3.3
MEDLINEFind literature relating to 1.2.3.3
MetaCyc1.2.3.3
Rhea expert-curated reactions1.2.3.3
UniProtKB/Swiss-Prot
P37063, POXB_LACPLQ54970, POXB_STRPN

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