ENZYME entry: EC 1.2.3.3
Accepted Name |
Pyruvate oxidase.
|
Alternative Name(s) |
Phosphate-dependent pyruvate oxidase. |
Pyruvic oxidase. |
Reaction catalysed |
Pyruvate + phosphate + O(2) <=> acetyl phosphate + CO(2) + H(2)O(2) |
Cofactor(s) |
FAD; Thiamine diphosphate.
|
Comment(s) |
- Two reducing equivalents are transferred from the resonant
carbanion/enamine forms of 2-hydroxyethyl-thiamine-diphosphate to the
adjacent flavin cofactor, yielding 2-acetyl-thiamine diphosphate
(AcThDP) and reduced flavin.
- FADH is reoxidized by O(2) to yield H(2)O(2) and FAD and AcThDP is
cleaved phosphorolytically to acetyl phosphate and thiamine
diphosphate.
|
Cross-references |
PROSITE | PDOC00166 |
BRENDA | 1.2.3.3 |
EC2PDB | 1.2.3.3 |
ExplorEnz | 1.2.3.3 |
PRIAM enzyme-specific profiles | 1.2.3.3 |
KEGG Ligand Database for Enzyme Nomenclature | 1.2.3.3 |
IUBMB Enzyme Nomenclature | 1.2.3.3 |
IntEnz | 1.2.3.3 |
MEDLINE | Find literature relating to 1.2.3.3 |
MetaCyc | 1.2.3.3 |
UniProtKB/Swiss-Prot |
|
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ENZYME /
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