A new class EC 7, Translocases, has been added to the EC list. It will be part of ENZYME from release 2018_10. Read more about EC 7 here.
ENZYME entry: EC 1.2.5.1
| Accepted Name |
|---|
| Pyruvate dehydrogenase (quinone).
|
| Alternative Name(s) |
|---|
| Pyruvate dehydrogenase. |
| Pyruvate dehydrogenase (cytochrome). |
| Pyruvate oxidase. |
| Reaction catalysed |
|---|
| Pyruvate + ubiquinone + H(2)O <=> acetate + CO(2) + ubiquinol |
| Cofactor(s) |
|---|
| FAD.
|
| Comment(s) |
|---|
- This bacterial enzyme is located on the inner surface of the
cytoplasmic membrane and coupled to the respiratory chain via
ubiquinone.
- Does not accept menaquinone.
- Activity is greatly enhanced by lipids.
- Requires thiamine diphosphate.
- The enzyme can also form acetoin.
|
| Cross-references |
|---|
| BRENDA | 1.2.5.1 |
| EC2PDB | 1.2.5.1 |
| ExplorEnz | 1.2.5.1 |
| PRIAM enzyme-specific profiles | 1.2.5.1 |
| KEGG Ligand Database for Enzyme Nomenclature | 1.2.5.1 |
| IUBMB Enzyme Nomenclature | 1.2.5.1 |
| IntEnz | 1.2.5.1 |
| MEDLINE | Find literature relating to 1.2.5.1 |
| MetaCyc | 1.2.5.1 |
| UniProtKB/Swiss-Prot |
|
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