Expasy logo

ENZYME

ENZYME entry: EC 1.2.5.1

PURL: https://purl.expasy.org/enzyme/EC/1.2.5.1
Accepted Name
pyruvate dehydrogenase (quinone)
Alternative Name(s)
pyruvate dehydrogenase
pyruvate dehydrogenase (cytochrome)
pyruvate oxidase
Reaction catalysed
a ubiquinone + pyruvate + H2O = a ubiquinol + acetate + CO2
Comment(s)
  • This bacterial enzyme is located on the inner surface of the cytoplasmic membrane and coupled to the respiratory chain via ubiquinone.
  • Does not accept menaquinone.
  • Activity is greatly enhanced by lipids.
  • Requires thiamine diphosphate.
  • The enzyme can also form acetoin.
Cross-references
Rhea expert-curated reactions1.2.5.1
ExplorEnz1.2.5.1
IUBMB Enzyme Nomenclature1.2.5.1
UniProtKB/Swiss-Prot
P07003, POXB_ECOLI
BRENDA1.2.5.1
MetaCyc1.2.5.1
KEGG Ligand Database for Enzyme Nomenclature1.2.5.1
EC2PDB1.2.5.1
MEDLINEFind literature relating to 1.2.5.1

View entry in original ENZYME format
View entry in raw text format (no links)
All UniProtKB/Swiss-Prot entries referenced in this entry, with possibility to download in different formats, align etc.
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.2.5.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.2.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.-.-.-