A new class EC 7, Translocases, has been added to the EC list. It will be part of ENZYME from release 2018_10. Read more about EC 7 here.
ENZYME entry: EC 1.21.3.3
| Accepted Name |
|---|
| Reticuline oxidase.
|
| Alternative Name(s) |
|---|
| Berberine bridge enzyme. |
| Berberine-bridge-forming enzyme. |
| Tetrahydroprotoberberine synthase. |
| Reaction catalysed |
|---|
| (S)-reticuline + O(2) <=> (S)-scoulerine + H(2)O(2) |
| Cofactor(s) |
|---|
| FAD.
|
| Comment(s) |
|---|
- Acts on (S)-reticuline and related compounds, converting the N-methyl
group into the methylene bridge ('berberine bridge') of (S)-
tetrahydroprotoberberines.
- The product of the reaction, (S)-scoulerine, is a precursor of
protopine, protoberberine and benzophenanthridine alkaloid
biosynthesis in plants.
- Formerly EC 1.5.3.9.
|
| Cross-references |
|---|
| PROSITE | PDOC00674 |
| BRENDA | 1.21.3.3 |
| EC2PDB | 1.21.3.3 |
| ExplorEnz | 1.21.3.3 |
| PRIAM enzyme-specific profiles | 1.21.3.3 |
| KEGG Ligand Database for Enzyme Nomenclature | 1.21.3.3 |
| IUBMB Enzyme Nomenclature | 1.21.3.3 |
| IntEnz | 1.21.3.3 |
| MEDLINE | Find literature relating to 1.21.3.3 |
| MetaCyc | 1.21.3.3 |
| UniProtKB/Swiss-Prot |
|
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