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ENZYME entry: EC 1.21.3.3

Accepted Name
Reticuline oxidase.
Alternative Name(s)
Berberine bridge enzyme.
Berberine-bridge-forming enzyme.
Tetrahydroprotoberberine synthase.
Reaction catalysed
(S)-reticuline + O(2) <=> (S)-scoulerine + H(2)O(2)
Cofactor(s)
FAD.
Comment(s)
  • Acts on (S)-reticuline and related compounds, converting the N-methyl group into the methylene bridge ('berberine bridge') of (S)- tetrahydroprotoberberines.
  • The product of the reaction, (S)-scoulerine, is a precursor of protopine, protoberberine and benzophenanthridine alkaloid biosynthesis in plants.
  • Formerly EC 1.5.3.9.
Cross-references
PROSITEPDOC00674
BRENDA1.21.3.3
EC2PDB1.21.3.3
ExplorEnz1.21.3.3
PRIAM enzyme-specific profiles1.21.3.3
KEGG Ligand Database for Enzyme Nomenclature1.21.3.3
IUBMB Enzyme Nomenclature1.21.3.3
IntEnz1.21.3.3
MEDLINEFind literature relating to 1.21.3.3
MetaCyc1.21.3.3
Rhea expert-curated reactions1.21.3.3
UniProtKB/Swiss-Prot
P30986, RETO_ESCCA;  P93479, RETO_PAPSO;  

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