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ENZYME entry: EC

Accepted Name
reticuline oxidase.
Alternative Name(s)
berberine bridge enzyme.
berberine-bridge-forming enzyme.
tetrahydroprotoberberine synthase.
Reaction catalysed
(S)-reticuline + O2 <=> (S)-scoulerine + H(+) + H2O2
  • Acts on (S)-reticuline and related compounds, converting the N-methyl group into the methylene bridge ('berberine bridge') of (S)- tetrahydroprotoberberines.
  • The product of the reaction, (S)-scoulerine, is a precursor of protopine, protoberberine and benzophenanthridine alkaloid biosynthesis in plants.
  • Formerly EC
PRIAM enzyme-specific profiles1.21.3.3
KEGG Ligand Database for Enzyme Nomenclature1.21.3.3
IUBMB Enzyme Nomenclature1.21.3.3
MEDLINEFind literature relating to
Rhea expert-curated reactions1.21.3.3
P30986, RETO_ESCCA;  P93479, RETO_PAPSO;  

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