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ENZYME entry: EC 1.21.98.3

Accepted Name
Anaerobic magnesium-protoporphyrin IX monomethyl ester cyclase.
Alternative Name(s)
MPE cyclase.
Reaction catalysed
Magnesium-protoporphyrin IX 13-monomethyl ester + 3 S-adenosyl-L-methionine + H(2)O <=> 3,8-divinyl protochlorophyllide a + 3 5'-deoxyadenosine + 3 L-methionine
Cofactor(s)
Adenosylcob(III)alamin; Iron-sulfur.
Comment(s)
  • This radical AdoMet enzyme participates in the biosynthesis of chlorophyllide a in anaerobic bacteria, catalyzing the formation of an isocyclic ring.
  • The same transformation is achieved in aerobic organisms by the oxygen-dependent EC 1.14.13.81.
  • Some facultative phototrophic bacteria, such as Rubrivivax gelatinosus, possess both enzymes.
Cross-references
BRENDA1.21.98.3
EC2PDB1.21.98.3
ExplorEnz1.21.98.3
PRIAM enzyme-specific profiles1.21.98.3
KEGG Ligand Database for Enzyme Nomenclature1.21.98.3
IUBMB Enzyme Nomenclature1.21.98.3
IntEnz1.21.98.3
MEDLINEFind literature relating to 1.21.98.3
MetaCyc1.21.98.3
UniProtKB/Swiss-Prot
P26168, BCHE_RHOCB;  Q9RFD3, BCHE_RHOS4;  Q7X2C7, BCHE_RUBGE;  
Q55373, BCHE_SYNY3;  

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