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ENZYME entry: EC 1.21.99.5

Accepted Name
Tetrachloroethene reductive dehalogenase.
Alternative Name(s)
Tetrachloroethene reductase.
Reaction catalysed
Trichloroethene + chloride + acceptor <=> tetrachloroethene + reduced acceptor
Cofactor(s)
Iron-sulfur.
Comment(s)
  • This enzyme allows the common pollutant tetrachloroethene to support bacterial growth and is responsible for disposal of a number of chlorinated hydrocarbons by this organism.
  • The reaction occurs in the reverse direction.
  • The enzyme also reduces trichloroethene to dichloroethene.
  • Although the physiological reductant is unknown, the supply of reductant in some organisms is via reduced menaquinone, itself formed from molecular hydrogen, via EC 1.12.5.1.
  • Methylviologen can act as electron donor.
  • Formerly EC 1.97.1.8.
Cross-references
BRENDA1.21.99.5
EC2PDB1.21.99.5
ExplorEnz1.21.99.5
PRIAM enzyme-specific profiles1.21.99.5
KEGG Ligand Database for Enzyme Nomenclature1.21.99.5
IUBMB Enzyme Nomenclature1.21.99.5
IntEnz1.21.99.5
MEDLINEFind literature relating to 1.21.99.5
MetaCyc1.21.99.5
Rhea expert-curated reactions1.21.99.5
UniProtKB/Swiss-Prot
Q8GJ31, PCEA2_DESHA;  Q8GJ27, PCEA_DEHRP;  Q848J2, PCEA_DESHA;  
Q8L172, PCEA_DESHY;  O68252, PCEA_SULMU;  

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