ENZYME entry: EC 1.21.99.5
| Accepted Name |
|---|
| Tetrachloroethene reductive dehalogenase.
|
| Alternative Name(s) |
|---|
| Tetrachloroethene reductase. |
| Reaction catalysed |
|---|
| Trichloroethene + chloride + acceptor <=> tetrachloroethene + reduced acceptor |
| Cofactor(s) |
|---|
| Iron-sulfur.
|
| Comment(s) |
|---|
- This enzyme allows the common pollutant tetrachloroethene to support
bacterial growth and is responsible for disposal of a number of
chlorinated hydrocarbons by this organism.
- The reaction occurs in the reverse direction.
- The enzyme also reduces trichloroethene to dichloroethene.
- Although the physiological reductant is unknown, the supply of
reductant in some organisms is via reduced menaquinone, itself formed
from molecular hydrogen, via EC 1.12.5.1.
- Methylviologen can act as electron donor.
- Formerly EC 1.97.1.8.
|
| Cross-references |
|---|
| BRENDA | 1.21.99.5 |
| EC2PDB | 1.21.99.5 |
| ExplorEnz | 1.21.99.5 |
| PRIAM enzyme-specific profiles | 1.21.99.5 |
| KEGG Ligand Database for Enzyme Nomenclature | 1.21.99.5 |
| IUBMB Enzyme Nomenclature | 1.21.99.5 |
| IntEnz | 1.21.99.5 |
| MEDLINE | Find literature relating to 1.21.99.5 |
| MetaCyc | 1.21.99.5 |
| Rhea expert-curated reactions | 1.21.99.5 |
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