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ENZYME entry: EC 1.3.1.100

Accepted Name
Chanoclavine-I aldehyde reductase.
Reaction catalysed
Dihydrochanoclavine-I aldehyde + NADP(+) <=> chanoclavine-I aldehyde + NADPH
Cofactor(s)
FMN.
Comment(s)
  • The enzyme participates in the biosynthesis of fumigaclavine C, an ergot alkaloid produced by some fungi of the Trichocomaceae family.
  • The enzyme catalyzes the reduction of chanoclavine-I aldehyde to dihydrochanoclavine-I aldehyde.
  • This hydrolyzes spontaneously to form 6,8-dimethyl-6,7- didehydroergoline, which is converted to festuclavine by EC 1.5.1.44.
Cross-references
BRENDA1.3.1.100
EC2PDB1.3.1.100
ExplorEnz1.3.1.100
PRIAM enzyme-specific profiles1.3.1.100
KEGG Ligand Database for Enzyme Nomenclature1.3.1.100
IUBMB Enzyme Nomenclature1.3.1.100
IntEnz1.3.1.100
MEDLINEFind literature relating to 1.3.1.100
MetaCyc1.3.1.100
Rhea expert-curated reactions1.3.1.100
UniProtKB/Swiss-Prot
Q4WZ70, EASA_ASPFU;  W6Q9S9, FGOX3_PENRF;  W6Q2D7, IFGG_PENRF;  

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