ENZYME entry: EC 1.3.1.100
| Accepted Name |
|---|
| Chanoclavine-I aldehyde reductase.
|
| Reaction catalysed |
|---|
| Dihydrochanoclavine-I aldehyde + NADP(+) <=> chanoclavine-I aldehyde + NADPH |
| Cofactor(s) |
|---|
| FMN.
|
| Comment(s) |
|---|
- The enzyme participates in the biosynthesis of fumigaclavine C,
an ergot alkaloid produced by some fungi of the Trichocomaceae
family.
- The enzyme catalyzes the reduction of chanoclavine-I aldehyde to
dihydrochanoclavine-I aldehyde.
- This hydrolyzes spontaneously to form 6,8-dimethyl-6,7-
didehydroergoline, which is converted to festuclavine by EC 1.5.1.44.
|
| Cross-references |
|---|
| BRENDA | 1.3.1.100 |
| EC2PDB | 1.3.1.100 |
| ExplorEnz | 1.3.1.100 |
| PRIAM enzyme-specific profiles | 1.3.1.100 |
| KEGG Ligand Database for Enzyme Nomenclature | 1.3.1.100 |
| IUBMB Enzyme Nomenclature | 1.3.1.100 |
| IntEnz | 1.3.1.100 |
| MEDLINE | Find literature relating to 1.3.1.100 |
| MetaCyc | 1.3.1.100 |
| UniProtKB/Swiss-Prot |
|
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