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ENZYME entry: EC 1.3.1.101

Accepted Name
2,3-bis-O-geranylgeranyl-sn-glycerol 1-phosphate reductase [NAD(P)H].
Alternative Name(s)
2,3-digeranylgeranylglycerophospholipid reductase.
DGGGPL reductase.
digeranylgeranylglycerophospholipid reductase.
Reaction catalysed
  • 2,3-bis-O-(phytanyl)-sn-glycerol 1-phosphate + 8 NADP(+) <=> 2,3-bis-O-(geranylgeranyl)-sn-glycerol 1-phosphate + 8 H(+) + 8 NADPH
  • 2,3-bis-O-(phytanyl)-sn-glycerol 1-phosphate + 8 NAD(+) <=> 2,3-bis-O-(geranylgeranyl)-sn-glycerol 1-phosphate + 8 H(+) + 8 NADH
Comment(s)
  • The enzyme from the archaeon Thermoplasma acidophilum is involved in the biosynthesis of membrane lipids.
  • In vivo the reaction occurs in the reverse direction with the formation of 2,3-bis-O-phytanyl-sn-glycerol 1-phosphate. cf. EC 1.3.7.11.
Cross-references
BRENDA1.3.1.101
EC2PDB1.3.1.101
ExplorEnz1.3.1.101
PRIAM enzyme-specific profiles1.3.1.101
KEGG Ligand Database for Enzyme Nomenclature1.3.1.101
IUBMB Enzyme Nomenclature1.3.1.101
IntEnz1.3.1.101
MEDLINEFind literature relating to 1.3.1.101
MetaCyc1.3.1.101
Rhea expert-curated reactions1.3.1.101
UniProtKB/Swiss-Prot
Q6L0M1, GGR_PICTO;  Q9HKS9, GGR_THEAC;  Q979Y7, GGR_THEVO;  

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