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A new class EC 7, Translocases, has been added to the EC list. It will be part of ENZYME from release 2018_10. Read more about EC 7 here.

ENZYME entry: EC 1.3.7.11

Accepted Name
2,3-bis-O-geranylgeranyl-sn-glycero-phospholipid reductase.
Alternative Name(s)
2,3-bis-O-geranylgeranyl-sn-glycerol 1-phosphate reductase (donor).
Reaction catalysed
A 2,3-bis-(O-phytanyl)-sn-glycero-phospholipid + 16 oxidized ferredoxin [iron-sulfur] cluster <=> a 2,3-bis-(O-geranylgeranyl)-sn-glycero-phospholipid + 16 reduced ferredoxin [iron-sulfur] cluster + 16 H(+)
Cofactor(s)
FAD.
Comment(s)
  • The enzyme is involved in the biosynthesis of archaeal membrane lipids.
  • It catalyzes the reduction of all 8 double bonds in 2,3-bis-O- geranylgeranyl-sn-glycero-phospholipids and all 4 double bonds in 3-O-geranylgeranyl-sn-glycerol phospholipids with comparable activity.
  • Unlike EC 1.3.1.101, this enzyme shows no activity with NADPH, and requires a dedicated ferredoxin.
  • Formerly EC 1.3.99.34.
Cross-references
BRENDA1.3.7.11
EC2PDB1.3.7.11
ExplorEnz1.3.7.11
PRIAM enzyme-specific profiles1.3.7.11
KEGG Ligand Database for Enzyme Nomenclature1.3.7.11
IUBMB Enzyme Nomenclature1.3.7.11
IntEnz1.3.7.11
MEDLINEFind literature relating to 1.3.7.11
MetaCyc1.3.7.11
UniProtKB/Swiss-Prot
Q12YW2, GGR1_METBU;  Q8TVE9, GGR1_METKA;  Q2NFZ1, GGR1_METST;  
O26377, GGR1_METTH;  Q12WF0, GGR2_METBU;  Q8TUV8, GGR2_METKA;  
Q2NFF7, GGR2_METST;  O27753, GGR2_METTH;  Q2NER9, GGR3_METST;  
O29786, GGR_ARCFU;  D4GSC3, GGR_HALVD;  A6UWL1, GGR_META3;  
Q8TQQ6, GGR_METAC;  Q0W349, GGR_METAR;  A7I9P9, GGR_METB6;  
Q465Z7, GGR_METBF;  Q2FUA4, GGR_METHJ;  Q57952, GGR_METJA;  
A2SQK1, GGR_METLZ;  A4FZB4, GGR_METM5;  A9A6R1, GGR_METM6;  
A6VJ23, GGR_METM7;  Q8PU50, GGR_METMA;  A3CST9, GGR_METMJ;  
Q6M083, GGR_METMP;  B8GGQ9, GGR_METPE;  A5UNX8, GGR_METS3;  
A0B573, GGR_METTP;  A6US00, GGR_METVS;  Q9V2B0, GGR_PYRAB;  
Q8U4J0, GGR_PYRFU;  O57920, GGR_PYRHO;  C5A6E5, GGR_THEGJ;  
Q5JE27, GGR_THEKO;  

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.3.7.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.3.-.-
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