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ENZYME entry: EC 1.3.7.11

Accepted Name
2,3-bis-O-geranylgeranyl-sn-glycero-phospholipid reductase.
Alternative Name(s)
2,3-bis-O-geranylgeranyl-sn-glycerol 1-phosphate reductase (donor).
Reaction catalysed
a 2,3-bis-O-phytanyl-sn-glycerol 1-phospholipid + 8 oxidized 2[4Fe-4S]-[ferredoxin] <=> a 2,3-bis-O-(geranylgeranyl)-sn-glycerol 1-phospholipid + 16 H(+) + 8 reduced 2[4Fe-4S]-[ferredoxin]
Comment(s)
  • The enzyme is involved in the biosynthesis of archaeal membrane lipids.
  • It catalyzes the reduction of all 8 double bonds in 2,3-bis-O- geranylgeranyl-sn-glycero-phospholipids and all 4 double bonds in 3-O-geranylgeranyl-sn-glycerol phospholipids with comparable activity.
  • Unlike EC 1.3.1.101, this enzyme shows no activity with NADPH, and requires a dedicated ferredoxin.
  • Formerly EC 1.3.99.34.
Cross-references
BRENDA1.3.7.11
EC2PDB1.3.7.11
ExplorEnz1.3.7.11
PRIAM enzyme-specific profiles1.3.7.11
KEGG Ligand Database for Enzyme Nomenclature1.3.7.11
IUBMB Enzyme Nomenclature1.3.7.11
IntEnz1.3.7.11
MEDLINEFind literature relating to 1.3.7.11
MetaCyc1.3.7.11
Rhea expert-curated reactions1.3.7.11
UniProtKB/Swiss-Prot
Q12YW2, GGR1_METBU;  Q12WF0, GGR2_METBU;  D4GSC3, GGR_HALVD;  
Q8TQQ6, GGR_METAC;  Q0W349, GGR_METAR;  A7I9P9, GGR_METB6;  
Q465Z7, GGR_METBF;  Q2FUA4, GGR_METHJ;  A2SQK1, GGR_METLZ;  
Q8PU50, GGR_METMA;  A3CST9, GGR_METMJ;  B8GGQ9, GGR_METPE;  
A0B573, GGR_METTP;  

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