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ENZYME entry: EC 1.3.1.107

Accepted Name
sanguinarine reductase.
Reaction catalysed
  • dihydrosanguinarine + NADP(+) <=> NADPH + sanguinarine
  • dihydrosanguinarine + NAD(+) <=> NADH + sanguinarine
  • dihydrochelirubine + NAD(+) <=> chelirubine + NADH
  • dihydrochelirubine + NADP(+) <=> chelirubine + NADPH
Comment(s)
  • The enzyme, purified from the California poppy (Eschscholzia californica), is involved in detoxifying the phytoalexin sanguinarine produced by poppy itself (cf. EC 1.5.3.12), when it binds to the cell wall of the poppy cell.
  • The reaction with NADPH is up to three times faster than that with NADH at low concentrations (<10 uM) of the dinucleotide.
  • At higher concentrations the reaction with NADPH is inhibited but not that with NADH.
Cross-references
BRENDA1.3.1.107
EC2PDB1.3.1.107
ExplorEnz1.3.1.107
PRIAM enzyme-specific profiles1.3.1.107
KEGG Ligand Database for Enzyme Nomenclature1.3.1.107
IUBMB Enzyme Nomenclature1.3.1.107
IntEnz1.3.1.107
MEDLINEFind literature relating to 1.3.1.107
MetaCyc1.3.1.107
Rhea expert-curated reactions1.3.1.107
UniProtKB/Swiss-Prot
D5JWB3, SARED_ESCCA

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