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ENZYME

ENZYME entry: EC 1.3.1.108

PURL: https://purl.expasy.org/enzyme/EC/1.3.1.108
Accepted Name
caffeoyl-CoA reductase
Alternative Name(s)
caffeoyl-CoA reductase-Etf complex
electron-bifurcating caffeoyl-CoA reductase
Reaction catalysed
hydrocaffeoyl-CoA + 2 reduced [2Fe-2S]-[ferredoxin] + 2 NAD(+) = (E)-caffeoyl-CoA + 2 oxidized [2Fe-2S]-[ferredoxin] + 2 NADH
Comment(s)
  • The enzyme, characterized from the bacterium Acetobacterium woodii, couples the endergonic ferredoxin reduction with NADH as reductant to the exergonic reduction of caffeoyl-CoA with the same reductant.
  • It uses the mechanism of electron bifurcation to overcome the steep energy barrier in ferredoxin reduction.
  • It also reduces 4-coumaroyl-CoA and feruloyl-CoA.
Cross-references
BRENDA1.3.1.108
EC2PDB1.3.1.108
ExplorEnz1.3.1.108
KEGG Ligand Database for Enzyme Nomenclature1.3.1.108
IUBMB Enzyme Nomenclature1.3.1.108
MEDLINEFind literature relating to 1.3.1.108
MetaCyc1.3.1.108
Rhea expert-curated reactions1.3.1.108
UniProtKB/Swiss-Prot
H6LGM6, CARC_ACEWDH6LGM7, CARD_ACEWDH6LGM8, CARE_ACEWD

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.3.1.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.3.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.-.-.-