Home  |  Contact

A new class EC 7, Translocases, has been added to the EC list. It will be part of ENZYME from release 2018_10. Read more about EC 7 here.

ENZYME entry: EC 1.3.1.108

Accepted Name
Caffeoyl-CoA reductase.
Alternative Name(s)
Caffeoyl-CoA reductase-Etf complex.
Electron-bifurcating caffeoyl-CoA reductase.
Reaction catalysed
3-(3,4-dihydroxyphenyl)propanoyl-CoA + 2 NAD(+) + 2 reduced ferredoxin [iron-sulfur] cluster <=> (2E)-3-(3,4-dihydroxyphenyl)prop-2-enoyl-CoA + 2 NADH + 2 oxidized ferredoxin [iron-sulfur] cluster
Cofactor(s)
FAD; Iron-sulfur.
Comment(s)
  • The enzyme, characterized from the bacterium Acetobacterium woodii, couples the endergonic ferredoxin reduction with NADH as reductant to the exergonic reduction of caffeoyl-CoA with the same reductant.
  • It uses the mechanism of electron bifurcation to overcome the steep energy barrier in ferredoxin reduction.
  • It also reduces 4-coumaroyl-CoA and feruloyl-CoA.
Cross-references
BRENDA1.3.1.108
EC2PDB1.3.1.108
ExplorEnz1.3.1.108
PRIAM enzyme-specific profiles1.3.1.108
KEGG Ligand Database for Enzyme Nomenclature1.3.1.108
IUBMB Enzyme Nomenclature1.3.1.108
IntEnz1.3.1.108
MEDLINEFind literature relating to 1.3.1.108
MetaCyc1.3.1.108
UniProtKB/Swiss-Prot
H6LGM6, CARC_ACEWD;  H6LGM7, CARD_ACEWD;  H6LGM8, CARE_ACEWD;  

View entry in original ENZYME format
View entry in raw text format (no links)
All UniProtKB/Swiss-Prot entries referenced in this entry, with possibility to download in different formats, align etc.
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.3.1.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.3.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.-.-.-