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ENZYME

ENZYME entry: EC 1.3.1.109

PURL: https://purl.expasy.org/enzyme/EC/1.3.1.109
Accepted Name
butanoyl-CoA dehydrogenase complex (NAD(+), ferredoxin)
Alternative Name(s)
bifurcating butanoyl-CoA dehydrogenase
butanoyl-CoA dehydrogenase/Etf complex
Reaction catalysed
butanoyl-CoA + 2 reduced [2Fe-2S]-[ferredoxin] + 2 NAD(+) = (2E)-butenoyl-CoA + 2 oxidized [2Fe-2S]-[ferredoxin] + 2 NADH
Comment(s)
  • The enzyme is a complex of a flavin-containing dehydrogenase component (Bcd) and an electron-transfer flavoprotein dimer (EtfAB).
  • The enzyme complex, isolated from the bacteria Acidaminococcus fermentans and butanoate-producing Clostridia species, couples the exergonic reduction of (E)-but-2-enoyl-CoA to butanoyl-CoA by NADH to the endergonic reduction of ferredoxin by NADH, using electron bifurcation to overcome the steep energy barrier in ferredoxin reduction.
Cross-references
BRENDA1.3.1.109
EC2PDB1.3.1.109
ExplorEnz1.3.1.109
KEGG Ligand Database for Enzyme Nomenclature1.3.1.109
IUBMB Enzyme Nomenclature1.3.1.109
MEDLINEFind literature relating to 1.3.1.109
MetaCyc1.3.1.109
Rhea expert-curated reactions1.3.1.109

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.3.1.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.3.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.-.-.-