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ENZYME entry: EC 1.3.1.112

Accepted Name
Anthocyanidin reductase ((2S)-flavan-3-ol-forming).
Reaction catalysed
  • A (2S,3R)-flavan-3-ol + 2 NADP(+) <=> an anthocyanidin with a 3-hydroxy group + 2 NADPH
  • A (2S,3S)-flavan-3-ol + 2 NADP(+) <=> an anthocyanidin with a 3-hydroxy group + 2 NADPH
Comment(s)
  • The enzyme, characterized from Vitis vinifera (grape), participates in the flavonoid biosynthesis pathway.
  • It catalyzes the double reduction of anthocyanidins, producing a mixture of (2S,3S)- and (2S,3R)-flavan-3-ols.
  • The enzyme catalyzes sequential hydride transfers to C-2 and C-4, respectively.
  • Epimerization at C-3 is achieved by tautomerization that occurs between the two hydride transfers.
  • Cf. EC 1.3.1.77.
Cross-references
BRENDA1.3.1.112
EC2PDB1.3.1.112
ExplorEnz1.3.1.112
PRIAM enzyme-specific profiles1.3.1.112
KEGG Ligand Database for Enzyme Nomenclature1.3.1.112
IUBMB Enzyme Nomenclature1.3.1.112
IntEnz1.3.1.112
MEDLINEFind literature relating to 1.3.1.112
MetaCyc1.3.1.112
UniProtKB/Swiss-Prot
Q7PCC4, ANRCH_VITVI;  Q5FB34, ANRCS_VITVI;  D7U6G6, ANRPN_VITVI;  

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