ENZYME entry: EC 1.3.1.114
Accepted Name |
3-dehydro-bile acid Delta(4,6)-reductase.
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Reaction catalysed |
- 3-oxocholan-24-oyl-CoA + NAD(+) <=> 3-oxochol-4-en-24-oyl-CoA + NADH
- 3-oxochol-4-en-24-oyl-CoA + NAD(+) <=> 3-oxochol-4,6-dien-24-oyl-CoA + NADH
- 12-alpha-hydroxy-3-oxocholan-24-oyl-CoA + NAD(+) <=> 12-alpha-hydroxy-3-oxochol-4-en-24-oyl-CoA + NADH
- 12-alpha-hydroxy-3-oxochol-4-en-24-oyl-CoA + NAD(+) <=> 12-alpha-hydroxy-3-oxochol-4,6-dien-24-oyl-CoA + NADH
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Cofactor(s) |
Flavoprotein.
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Comment(s) |
- The enzyme, characterized from the bacterium Clostridium scindens,
participates in the bile acid 7-alpha-dehydroxylation pathway.
- The enzyme catalyzes two subsequent reductions of the double bonds
within the bile acid A/B rings, following 7-alpha-dehydration.
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Cross-references |
BRENDA | 1.3.1.114 |
EC2PDB | 1.3.1.114 |
ExplorEnz | 1.3.1.114 |
PRIAM enzyme-specific profiles | 1.3.1.114 |
KEGG Ligand Database for Enzyme Nomenclature | 1.3.1.114 |
IUBMB Enzyme Nomenclature | 1.3.1.114 |
IntEnz | 1.3.1.114 |
MEDLINE | Find literature relating to 1.3.1.114 |
MetaCyc | 1.3.1.114 |
Rhea expert-curated reactions | 1.3.1.114 |
UniProtKB/Swiss-Prot |
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