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ENZYME entry: EC 1.3.1.114

Accepted Name
3-dehydro-bile acid Delta(4,6)-reductase.
Reaction catalysed
  • 3-oxocholan-24-oyl-CoA + NAD(+) <=> 3-oxochol-4-en-24-oyl-CoA + NADH
  • 3-oxochol-4-en-24-oyl-CoA + NAD(+) <=> 3-oxochol-4,6-dien-24-oyl-CoA + NADH
  • 12-alpha-hydroxy-3-oxocholan-24-oyl-CoA + NAD(+) <=> 12-alpha-hydroxy-3-oxochol-4-en-24-oyl-CoA + NADH
  • 12-alpha-hydroxy-3-oxochol-4-en-24-oyl-CoA + NAD(+) <=> 12-alpha-hydroxy-3-oxochol-4,6-dien-24-oyl-CoA + NADH
Cofactor(s)
Flavoprotein.
Comment(s)
  • The enzyme, characterized from the bacterium Clostridium scindens, participates in the bile acid 7-alpha-dehydroxylation pathway.
  • The enzyme catalyzes two subsequent reductions of the double bonds within the bile acid A/B rings, following 7-alpha-dehydration.
Cross-references
BRENDA1.3.1.114
EC2PDB1.3.1.114
ExplorEnz1.3.1.114
PRIAM enzyme-specific profiles1.3.1.114
KEGG Ligand Database for Enzyme Nomenclature1.3.1.114
IUBMB Enzyme Nomenclature1.3.1.114
IntEnz1.3.1.114
MEDLINEFind literature relating to 1.3.1.114
MetaCyc1.3.1.114
Rhea expert-curated reactions1.3.1.114
UniProtKB/Swiss-Prot
B0NAQ4, BAIN_CLOS5

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