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ENZYME entry: EC 1.3.1.120

Accepted Name
Cyclohexane-1-carbonyl-CoA reductase (NADP(+)).
Alternative Name(s)
1-cyclohexenylcarbonyl-CoA reductase.
Reaction catalysed
Cyclohexane-1-carbonyl-CoA + NADP(+) <=> cyclohex-1-ene-1-carbonyl-CoA + NADPH
Comment(s)
  • The enzyme, characterized from the bacterium Streptomyces collinus, is involved in a pathway that transforms shikimate to cyclohexane-1- carbonyl-CoA by a series of dehydration and double-bond reduction steps.
  • Most of the steps in this process occur with the carboxylic acid activated as a coenzyme A thioester.
  • The enzyme catalyzes three steps in this pathway, also acting on (3R,4R)-3,4-dihydroxy-3,4-dihydrobenzoyl-CoA and (5S)-5- hydroxycyclohex-1-ene-1-carbonyl-CoA.
Cross-references
BRENDA1.3.1.120
EC2PDB1.3.1.120
ExplorEnz1.3.1.120
PRIAM enzyme-specific profiles1.3.1.120
KEGG Ligand Database for Enzyme Nomenclature1.3.1.120
IUBMB Enzyme Nomenclature1.3.1.120
IntEnz1.3.1.120
MEDLINEFind literature relating to 1.3.1.120
MetaCyc1.3.1.120
Rhea expert-curated reactions1.3.1.120
UniProtKB/Swiss-Prot
P95727, CHCA_STRCU

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