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ENZYME entry: EC 1.3.1.122

Accepted Name
(S)-8-oxocitronellyl enol synthase.
Alternative Name(s)
Iridoid synthase.
Reaction catalysed
(S)-8-oxocitronellyl enol + NAD(P)(+) <=> (6E)-8-oxogeranial + NAD(P)H
Comment(s)
  • Isolated from the plants Catharanthus roseus, Olea europaea (common olive), and several Nepeta species.
  • The enzyme reduces 8-oxogeranial, generating an unstable product that is subsequently cyclized into several possible products, either non- enzymically or by dedicated cyclases.
  • The products, known as iridoids, are involved in the biosynthesis of many indole alkaloids.
  • Cf. EC 1.3.1.123.
  • Formerly EC 1.3.1.99.
Cross-references
BRENDA1.3.1.122
EC2PDB1.3.1.122
ExplorEnz1.3.1.122
PRIAM enzyme-specific profiles1.3.1.122
KEGG Ligand Database for Enzyme Nomenclature1.3.1.122
IUBMB Enzyme Nomenclature1.3.1.122
IntEnz1.3.1.122
MEDLINEFind literature relating to 1.3.1.122
MetaCyc1.3.1.122
Rhea expert-curated reactions1.3.1.122
UniProtKB/Swiss-Prot
A0A1C9CX56, CYC1_CAMAC;  A0A1C9CX66, CYC2_CAMAC;  K7WDL7, IRIS_CATRO;  
A0A221J5W8, ISY1_NEPCA;  A0A221J5X3, ISY1_NEPRA;  A0A221J5X1, ISY2_NEPCA;  
A0A221J5X6, ISY2_NEPRA;  A0A221J5P3, ISY_ANTMA;  

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