Expasy logo

ENZYME

ENZYME entry: EC 1.3.1.122

PURL: https://purl.expasy.org/enzyme/EC/1.3.1.122
Accepted Name
(S)-8-oxocitronellyl enol synthase
Alternative Name(s)
iridoid synthase
Reaction catalysed
  • (S)-8-oxocitronellyl enol + NADP(+) = (6E)-8-oxogeranial + NADPH + H(+)
  • (S)-8-oxocitronellyl enol + NAD(+) = (6E)-8-oxogeranial + NADH + H(+)
Comment(s)
  • Isolated from the plants Catharanthus roseus, Olea europaea (common olive), and several Nepeta species.
  • The enzyme reduces 8-oxogeranial, generating an unstable product that is subsequently cyclized into several possible products, either non- enzymically or by dedicated cyclases.
  • The products, known as iridoids, are involved in the biosynthesis of many indole alkaloids. cf. EC 1.3.1.123.
  • Formerly EC 1.3.1.99.
Cross-references
BRENDA1.3.1.122
EC2PDB1.3.1.122
ExplorEnz1.3.1.122
KEGG Ligand Database for Enzyme Nomenclature1.3.1.122
IUBMB Enzyme Nomenclature1.3.1.122
MEDLINEFind literature relating to 1.3.1.122
MetaCyc1.3.1.122
Rhea expert-curated reactions1.3.1.122
UniProtKB/Swiss-Prot
A0A1C9CX56, CYC1_CAMACA0A1C9CX66, CYC2_CAMACK7WDL7, IRIS_CATRO
A0A221J5W8, ISY1_NEPCAA0A221J5X3, ISY1_NEPRAA0A221J5X1, ISY2_NEPCA
A0A221J5X6, ISY2_NEPRAA0A221J5P3, ISY_ANTMA

View entry in original ENZYME format
View entry in raw text format (no links)
All UniProtKB/Swiss-Prot entries referenced in this entry, with possibility to download in different formats, align etc.
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.3.1.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.3.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.-.-.-