ENZYME entry: EC 1.3.1.22
Accepted Name |
3-oxo-5alpha-steroid 4-dehydrogenase (NADP(+)).
|
Alternative Name(s) |
3-oxo-5alpha-steroid 4-dehydrogenase. |
cholestenone 5alpha-reductase. |
Reaction catalysed |
a 3-oxo-5alpha-steroid + NADP(+) <=> a 3-oxo-Delta(4)-steroid + H(+) + NADPH |
Comment(s) |
- The enzyme catalyzes the conversion of assorted 3-oxo-Delta(4)
steroids into their corresponding 5alpha form.
- Substrates for the mammalian enzyme include testosterone,
progesterone, and corticosterone.
- Substrates for the plant enzyme are brassinosteroids such as campest-
4-en-3-one and (22alpha)-hydroxy-campest-4-en-3-one. cf. EC 1.3.99.5.
- Formerly EC 1.3.1.4 and EC 1.3.1.30.
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Cross-references |
BRENDA | 1.3.1.22 |
EC2PDB | 1.3.1.22 |
ExplorEnz | 1.3.1.22 |
PRIAM enzyme-specific profiles | 1.3.1.22 |
KEGG Ligand Database for Enzyme Nomenclature | 1.3.1.22 |
IUBMB Enzyme Nomenclature | 1.3.1.22 |
IntEnz | 1.3.1.22 |
MEDLINE | Find literature relating to 1.3.1.22 |
MetaCyc | 1.3.1.22 |
Rhea expert-curated reactions | 1.3.1.22 |
UniProtKB/Swiss-Prot |
Q38944, DET2_ARATH; | I1HTF7, DET2_BRADI; | Q2QDF6, DET2_GOSHI; |
Q5K2N1, DET2_SOLLC; | D2HBV9, PORED_AILME; | Q5RIU9, PORED_DANRE; |
Q9H8P0, PORED_HUMAN; | C7T2J9, PORED_MESAU; | Q9WUP4, PORED_MOUSE; |
Q5RJM1, PORED_RAT; | Q8AVI9, PORED_XENLA; | Q0P4J9, PORED_XENTR; |
A5PJS2, S5A1_BOVIN; | P18405, S5A1_HUMAN; | Q28891, S5A1_MACFA; |
Q68FF9, S5A1_MOUSE; | P24008, S5A1_RAT; | P31213, S5A2_HUMAN; |
Q28892, S5A2_MACFA; | Q99N99, S5A2_MOUSE; | O18765, S5A2_PIG; |
P31214, S5A2_RAT; |
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UniProtKB/Swiss-Prot entries corresponding to 1.3.1.-
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