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ENZYME entry: EC 1.3.1.22

Accepted Name
3-oxo-5alpha-steroid 4-dehydrogenase (NADP(+)).
Alternative Name(s)
3-oxo-5alpha-steroid 4-dehydrogenase.
cholestenone 5alpha-reductase.
Reaction catalysed
a 3-oxo-5alpha-steroid + NADP(+) <=> a 3-oxo-Delta(4)-steroid + H(+) + NADPH
Comment(s)
  • The enzyme catalyzes the conversion of assorted 3-oxo-Delta(4) steroids into their corresponding 5alpha form.
  • Substrates for the mammalian enzyme include testosterone, progesterone, and corticosterone.
  • Substrates for the plant enzyme are brassinosteroids such as campest- 4-en-3-one and (22alpha)-hydroxy-campest-4-en-3-one.
  • Cf. EC 1.3.99.5.
  • Formerly EC 1.3.1.4 and EC 1.3.1.30.
Cross-references
BRENDA1.3.1.22
EC2PDB1.3.1.22
ExplorEnz1.3.1.22
PRIAM enzyme-specific profiles1.3.1.22
KEGG Ligand Database for Enzyme Nomenclature1.3.1.22
IUBMB Enzyme Nomenclature1.3.1.22
IntEnz1.3.1.22
MEDLINEFind literature relating to 1.3.1.22
MetaCyc1.3.1.22
Rhea expert-curated reactions1.3.1.22
UniProtKB/Swiss-Prot
Q38944, DET2_ARATH;  I1HTF7, DET2_BRADI;  Q2QDF6, DET2_GOSHI;  
Q5K2N1, DET2_SOLLC;  D2HBV9, PORED_AILME;  Q5RIU9, PORED_DANRE;  
Q9H8P0, PORED_HUMAN;  C7T2J9, PORED_MESAU;  Q9WUP4, PORED_MOUSE;  
Q5RJM1, PORED_RAT;  Q8AVI9, PORED_XENLA;  Q0P4J9, PORED_XENTR;  
A5PJS2, S5A1_BOVIN;  P18405, S5A1_HUMAN;  Q28891, S5A1_MACFA;  
Q68FF9, S5A1_MOUSE;  P24008, S5A1_RAT;  P31213, S5A2_HUMAN;  
Q28892, S5A2_MACFA;  Q99N99, S5A2_MOUSE;  O18765, S5A2_PIG;  
P31214, S5A2_RAT;  

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