Home  |  Contact

ENZYME entry: EC 1.3.1.3

Accepted Name
Delta(4)-3-oxosteroid 5beta-reductase.
Alternative Name(s)
3-oxo-Delta(4)-steroid 5beta-reductase.
5beta-reductase.
androstenedione 5beta-reductase.
cholestenone 5beta-reductase.
cortisone 5beta-reductase.
cortisone beta-reductase.
cortisone Delta(4)-5beta-reductase.
Delta(4)-3-ketosteroid 5beta-reductase.
Delta(4)-5beta-reductase.
Delta(4)-hydrogenase.
steroid 5beta-reductase.
testosterone 5beta-reductase.
Reaction catalysed
  • 5beta-cholestan-3-one + NADP(+) <=> cholest-4-en-3-one + H(+) + NADPH
  • 4,5beta-dihydrocortisone + NADP(+) <=> cortisone + H(+) + NADPH
Comment(s)
  • The enzyme from human efficiently catalyzes the reduction of progesterone, androstenedione, 17alpha-hydroxyprogesterone and testosterone to 5beta-reduced metabolites; it can also act on aldosterone, corticosterone and cortisol, but to a lesser extent.
  • The bile acid intermediates 7alpha,12alpha-dihydroxy-4-cholesten-3- one and 7alpha-hydroxy-4-cholesten-3-one can also act as substrates.
Cross-references
BRENDA1.3.1.3
EC2PDB1.3.1.3
ExplorEnz1.3.1.3
PRIAM enzyme-specific profiles1.3.1.3
KEGG Ligand Database for Enzyme Nomenclature1.3.1.3
IUBMB Enzyme Nomenclature1.3.1.3
IntEnz1.3.1.3
MEDLINEFind literature relating to 1.3.1.3
MetaCyc1.3.1.3
Rhea expert-curated reactions1.3.1.3
UniProtKB/Swiss-Prot
Q6PQJ9, 5BPOR_DIGLA;  P51857, AK1D1_HUMAN;  Q8VCX1, AK1D1_MOUSE;  
Q9TV64, AK1D1_RABIT;  P31210, AK1D1_RAT;  Q9STX2, VEP1_ARATH;  

View entry in original ENZYME format
View entry in raw text format (no links)
All UniProtKB/Swiss-Prot entries referenced in this entry, with possibility to download in different formats, align etc.
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.3.1.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.3.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.-.-.-