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ENZYME

ENZYME entry: EC 1.3.1.3

PURL: https://purl.expasy.org/enzyme/EC/1.3.1.3
Accepted Name
Delta(4)-3-oxosteroid 5beta-reductase
Alternative Name(s)
3-oxo-Delta(4)-steroid 5beta-reductase
5beta-reductase
androstenedione 5beta-reductase
cholestenone 5beta-reductase
cortisone 5beta-reductase
cortisone beta-reductase
cortisone Delta(4)-5beta-reductase
Delta(4)-3-ketosteroid 5beta-reductase
Delta(4)-5beta-reductase
Delta(4)-hydrogenase
steroid 5beta-reductase
testosterone 5beta-reductase
Reaction catalysed
a 3-oxo-5beta-steroid + NADP(+) = a 3-oxo-Delta(4)-steroid + NADPH + H(+)
Comment(s)
  • The enzyme from human efficiently catalyzes the reduction of progesterone, androstenedione, 17alpha-hydroxyprogesterone and testosterone to 5beta-reduced metabolites; it can also act on aldosterone, corticosterone and cortisol, but to a lesser extent.
  • The bile acid intermediates 7alpha,12alpha-dihydroxy-4-cholesten-3- one and 7alpha-hydroxy-4-cholesten-3-one can also act as substrates.
Cross-references
BRENDA1.3.1.3
EC2PDB1.3.1.3
ExplorEnz1.3.1.3
KEGG Ligand Database for Enzyme Nomenclature1.3.1.3
IUBMB Enzyme Nomenclature1.3.1.3
MEDLINEFind literature relating to 1.3.1.3
MetaCyc1.3.1.3
Rhea expert-curated reactions1.3.1.3
UniProtKB/Swiss-Prot
Q6PQJ9, 5BPOR_DIGLAP51857, AK1D1_HUMANQ8VCX1, AK1D1_MOUSE
Q9TV64, AK1D1_RABITP31210, AK1D1_RATQ9STX2, VEP1_ARATH

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.3.1.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.3.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.-.-.-