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ENZYME entry: EC 1.3.1.3

Accepted Name
Delta(4)-3-oxosteroid 5-beta-reductase.
Alternative Name(s)
3-oxo-Delta(4)-steroid 5-beta-reductase.
5-beta-reductase.
Androstenedione 5-beta-reductase.
Cholestenone 5-beta-reductase.
Cortisone 5-beta-reductase.
Cortisone beta-reductase.
Cortisone Delta(4)-5-beta-reductase.
Delta(4)-3-ketosteroid 5-beta-reductase.
Delta(4)-5-beta-reductase.
Delta(4)-hydrogenase.
Steroid 5-beta-reductase.
Testosterone 5-beta-reductase.
Reaction catalysed
  • 5-beta-cholestan-3-one + NADP(+) <=> cholest-4-en-3-one + NADPH
  • 17,21-dihydroxy-5-beta-pregnane-3,11,20-trione + NADP(+) <=> cortisone + NADPH
Comment(s)
  • The enzyme from human efficiently catalyzes the reduction of progesterone, androstenedione, 17-alpha-hydroxyprogesterone and testosterone to 5-beta-reduced metabolites; it can also act on aldosterone, corticosterone and cortisol, but to a lesser extent.
  • The bile acid intermediates 7-alpha,12-alpha-dihydroxy-4-cholesten-3- one and 7-alpha-hydroxy-4-cholesten-3-one can also act as substrates.
Cross-references
PROSITEPDOC00061
BRENDA1.3.1.3
EC2PDB1.3.1.3
ExplorEnz1.3.1.3
PRIAM enzyme-specific profiles1.3.1.3
KEGG Ligand Database for Enzyme Nomenclature1.3.1.3
IUBMB Enzyme Nomenclature1.3.1.3
IntEnz1.3.1.3
MEDLINEFind literature relating to 1.3.1.3
MetaCyc1.3.1.3
Rhea expert-curated reactions1.3.1.3
UniProtKB/Swiss-Prot
Q6PQJ9, 5BPOR_DIGLA;  P51857, AK1D1_HUMAN;  Q8VCX1, AK1D1_MOUSE;  
Q9TV64, AK1D1_RABIT;  P31210, AK1D1_RAT;  Q9STX2, VEP1_ARATH;  

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