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ENZYME entry: EC 1.3.1.34

Accepted Name
2,4-dienoyl-CoA reductase [(2E)-enoyl-CoA-producing].
Alternative Name(s)
2,4-dienoyl-CoA reductase (NADPH).
4-enoyl-CoA reductase (NADPH).
Reaction catalysed
  • a 4,5-saturated-(2E)-enoyl-CoA + NADP(+) <=> a (2E,4E)-dienoyl-CoA + H(+) + NADPH
  • a (2E,4Z)-dienoyl-CoA + H(+) + NADPH <=> a 4,5-saturated-(2E)-enoyl-CoA + NADP(+)
Comment(s)
  • This bacterial enzyme catalyzes the reduction of either (2E,4E)-2,4- dienoyl-CoA or (2E,4Z)-2,4-dienoyl-CoA to (2E)-2-enoyl-CoA.
  • The enzyme from Escherichia coli contains FAD, FMN, and an [4Fe-4S] iron sulfur cluster.
  • Cf. EC 1.3.1.124.
Cross-references
BRENDA1.3.1.34
EC2PDB1.3.1.34
ExplorEnz1.3.1.34
PRIAM enzyme-specific profiles1.3.1.34
KEGG Ligand Database for Enzyme Nomenclature1.3.1.34
IUBMB Enzyme Nomenclature1.3.1.34
IntEnz1.3.1.34
MEDLINEFind literature relating to 1.3.1.34
MetaCyc1.3.1.34
Rhea expert-curated reactions1.3.1.34
UniProtKB/Swiss-Prot
O34717, FADH_BACSU;  P42593, FADH_ECOLI;  

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