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ENZYME

ENZYME entry: EC 1.3.1.124

Accepted Name
2,4-dienoyl-CoA reductase [(3E)-enoyl-CoA-producing]
Alternative Name(s)
Delta(2),Delta(4)-dienoyl-CoA reductase
Reaction catalysed
  • a (2E,4E)-dienoyl-CoA + H(+) + NADPH = a 4,5-saturated-(3E)-enoyl-CoA + NADP(+)
  • a (2E,4Z)-dienoyl-CoA + H(+) + NADPH = a 4,5-saturated-(3E)-enoyl-CoA + NADP(+)
Comment(s)
  • This enzyme, characterized from eukaryotic organisms, catalyzes the reduction of either (2E,4E)-2,4-dienoyl-CoA or (2E,4Z)-2,4-dienoyl- CoA to (3E)-3-enoyl-CoA.
  • The best substrates for the enzyme from bovine liver have a chain- length of 8 or 10.
  • Mammals possess both mitochondrial and peroxisomal variants of this enzyme. cf. EC 1.3.1.34.
Cross-references
BRENDA1.3.1.124
EC2PDB1.3.1.124
ExplorEnz1.3.1.124
PRIAM enzyme-specific profiles1.3.1.124
KEGG Ligand Database for Enzyme Nomenclature1.3.1.124
IUBMB Enzyme Nomenclature1.3.1.124
IntEnz1.3.1.124
MEDLINEFind literature relating to 1.3.1.124
MetaCyc1.3.1.124
Rhea expert-curated reactions1.3.1.124
UniProtKB/Swiss-Prot
Q23116, DEC12_CAEELQ9LTV6, DECR2_ARATHQ6NV34, DECR2_DANRE
Q9NUI1, DECR2_HUMANQ9WV68, DECR2_MOUSEQ5RBV3, DECR2_PONAB
Q9Z2M4, DECR2_RATQ22230, DECR_CAEELQ16698, DECR_HUMAN
Q9CQ62, DECR_MOUSEQ64591, DECR_RATP32573, SPS19_YEAST

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.3.1.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.3.-.-
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