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ENZYME entry: EC 1.3.1.124

Accepted Name
2,4-dienoyl-CoA reductase ((3E)-enoyl-CoA-producing).
Alternative Name(s)
Delta(2),Delta(4)-dienoyl-CoA reductase.
Reaction catalysed
  • A (3E)-3-enoyl-CoA + NADP(+) <=> a (2E,4E)-2,4-dienoyl-CoA + NADPH
  • A (3E)-3-enoyl-CoA + NADP(+) <=> a (2E,4Z)-2,4-dienoyl-CoA + NADPH
Comment(s)
  • This enzyme, characterized from eukaryotic organisms, catalyzes the reduction of either (2E,4E)-2,4-dienoyl-CoA or (2E,4Z)-2,4-dienoyl- CoA to (3E)-3-enoyl-CoA.
  • The best substrates for the enzyme from bovine liver have a chain- length of 8 or 10.
  • Mammals possess both mitochondrial and peroxisomal variants of this enzyme.
  • Cf. EC 1.3.1.34.
Cross-references
BRENDA1.3.1.124
EC2PDB1.3.1.124
ExplorEnz1.3.1.124
PRIAM enzyme-specific profiles1.3.1.124
KEGG Ligand Database for Enzyme Nomenclature1.3.1.124
IUBMB Enzyme Nomenclature1.3.1.124
IntEnz1.3.1.124
MEDLINEFind literature relating to 1.3.1.124
MetaCyc1.3.1.124
Rhea expert-curated reactions1.3.1.124
UniProtKB/Swiss-Prot
Q23116, DEC12_CAEEL;  Q9LTV6, DECR2_ARATH;  Q6NV34, DECR2_DANRE;  
Q9NUI1, DECR2_HUMAN;  Q9WV68, DECR2_MOUSE;  Q5RBV3, DECR2_PONAB;  
Q9Z2M4, DECR2_RAT;  Q22230, DECR_CAEEL;  Q16698, DECR_HUMAN;  
Q9CQ62, DECR_MOUSE;  Q64591, DECR_RAT;  P32573, SPS19_YEAST;  

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