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ENZYME entry: EC 1.3.1.39

Accepted Name
Enoyl-[acyl-carrier-protein] reductase (NADPH, Re-specific).
Alternative Name(s)
Acyl-ACP dehydrogenase.
Enoyl-[acyl-carrier-protein] reductase (NADPH, A-specific).
Reaction catalysed
An acyl-[acyl-carrier protein] + NADP(+) <=> a trans-2,3-dehydroacyl-[acyl-carrier protein] + NADPH
Comment(s)
  • This enzyme completes each cycle of fatty acid elongation by catalyzing the stereospecific reduction of the double bond at position 2 of a growing fatty acid chain, while linked to an acyl- carrier protein.
  • It is one of the activities of EC 2.3.1.85.
  • The mammalian enzyme is Re-specific with respect to NADP(+) (cf. EC 1.3.1.10 and and EC 1.3.1.104).
Cross-references
BRENDA1.3.1.39
EC2PDB1.3.1.39
ExplorEnz1.3.1.39
PRIAM enzyme-specific profiles1.3.1.39
KEGG Ligand Database for Enzyme Nomenclature1.3.1.39
IUBMB Enzyme Nomenclature1.3.1.39
IntEnz1.3.1.39
MEDLINEFind literature relating to 1.3.1.39
MetaCyc1.3.1.39
UniProtKB/Swiss-Prot
Q2FZQ3, FABI_STAA8;  Q6GI75, FABI_STAAR;  Q71SP7, FAS_BOVIN;  
P12276, FAS_CHICK;  P49327, FAS_HUMAN;  P19096, FAS_MOUSE;  
P12785, FAS_RAT;  

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