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ENZYME entry: EC 1.3.1.54

Accepted Name
precorrin-6A reductase.
Alternative Name(s)
precorrin-6X reductase.
precorrin-6Y:NADP(+) oxidoreductase.
Reaction catalysed
NADP(+) + precorrin-6B <=> 2 H(+) + NADPH + precorrin-6A
Comment(s)
  • The enzyme, which participates in the aerobic (late cobalt insertion) pathway of adenosylcobalamin biosynthesis, catalyzes the reduction of the double bond between C-18 and C-19 of precorrin-6A.
  • See EC 1.3.1.106 for the corresponding enzyme that participates in the anaerobic cobalamin biosynthesis pathway.
Cross-references
BRENDA1.3.1.54
EC2PDB1.3.1.54
ExplorEnz1.3.1.54
PRIAM enzyme-specific profiles1.3.1.54
KEGG Ligand Database for Enzyme Nomenclature1.3.1.54
IUBMB Enzyme Nomenclature1.3.1.54
IntEnz1.3.1.54
MEDLINEFind literature relating to 1.3.1.54
MetaCyc1.3.1.54
Rhea expert-curated reactions1.3.1.54
UniProtKB/Swiss-Prot
P9WP88, COBK_MYCTO;  P9WP89, COBK_MYCTU;  O68098, COBK_RHOCB;  
Q53139, COBK_RHOER;  P21920, COBK_SINSX;  

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