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ENZYME entry: EC 1.3.1.74

Accepted Name
2-alkenal reductase [NAD(P)(+)].
Alternative Name(s)
2-alkenal reductase.
NAD(P)H-dependent alkenal/one oxidoreductase.
NADPH:2-alkenal alpha,beta-hydrogenase.
Reaction catalysed
  • an n-alkanal + NAD(+) <=> an alk-2-enal + H(+) + NADH
  • an n-alkanal + NADP(+) <=> an alk-2-enal + H(+) + NADPH
Comment(s)
  • Highly specific for 4-hydroxynon-2-enal and non-2-enal.
  • Alk-2-enals of shorter chain have lower affinities.
  • Exhibits high activities also for alk-2-enones such as but-3-en-2-one and pent-3-en-2-one.
  • Inactive with cyclohex-2-en-1-one and 12-oxophytodienoic acid.
  • Involved in the detoxification of alpha,beta-unsaturated aldehydes and ketones (cf. EC 1.3.1.102).
Cross-references
BRENDA1.3.1.74
EC2PDB1.3.1.74
ExplorEnz1.3.1.74
PRIAM enzyme-specific profiles1.3.1.74
KEGG Ligand Database for Enzyme Nomenclature1.3.1.74
IUBMB Enzyme Nomenclature1.3.1.74
IntEnz1.3.1.74
MEDLINEFind literature relating to 1.3.1.74
MetaCyc1.3.1.74
Rhea expert-curated reactions1.3.1.74
UniProtKB/Swiss-Prot
Q39172, AER_ARATH;  Q39173, P2_ARATH;  Q3SZJ4, PTGR1_BOVIN;  
Q9EQZ5, PTGR1_CAVPO;  Q14914, PTGR1_HUMAN;  Q91YR9, PTGR1_MOUSE;  
Q29073, PTGR1_PIG;  Q28719, PTGR1_RABIT;  P97584, PTGR1_RAT;  

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