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ENZYME

ENZYME entry: EC 1.3.1.74

PURL: https://purl.expasy.org/enzyme/EC/1.3.1.74
Accepted Name
2-alkenal reductase [NAD(P)(+)]
Alternative Name(s)
2-alkenal reductase
NAD(P)H-dependent alkenal/one oxidoreductase
NADPH:2-alkenal alpha,beta-hydrogenase
Reaction catalysed
  • an n-alkanal + NAD(+) = an alk-2-enal + NADH + H(+)
  • an n-alkanal + NADP(+) = an alk-2-enal + NADPH + H(+)
Comment(s)
  • Highly specific for 4-hydroxynon-2-enal and non-2-enal.
  • Alk-2-enals of shorter chain have lower affinities.
  • Exhibits high activities also for alk-2-enones such as but-3-en-2-one and pent-3-en-2-one.
  • Inactive with cyclohex-2-en-1-one and 12-oxophytodienoic acid.
  • Involved in the detoxification of alpha,beta-unsaturated aldehydes and ketones (cf. EC 1.3.1.102).
Cross-references
BRENDA1.3.1.74
EC2PDB1.3.1.74
ExplorEnz1.3.1.74
KEGG Ligand Database for Enzyme Nomenclature1.3.1.74
IUBMB Enzyme Nomenclature1.3.1.74
MEDLINEFind literature relating to 1.3.1.74
MetaCyc1.3.1.74
Rhea expert-curated reactions1.3.1.74
UniProtKB/Swiss-Prot
Q39172, AER_ARATHQ39173, P2_ARATHQ3SZJ4, PTGR1_BOVIN
Q9EQZ5, PTGR1_CAVPOQ14914, PTGR1_HUMANQ91YR9, PTGR1_MOUSE
Q29073, PTGR1_PIGQ28719, PTGR1_RABITP97584, PTGR1_RAT

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.3.1.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.3.-.-
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