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ENZYME entry: EC 1.3.1.78

Accepted Name
Arogenate dehydrogenase (NADP(+)).
Alternative Name(s)
Arogenic dehydrogenase.
Pretyrosine dehydrogenase.
TyrA(a).
TyrAAT1.
TyrAAT2.
Reaction catalysed
L-arogenate + NADP(+) <=> L-tyrosine + NADPH + CO(2)
Comment(s)
  • Arogenate dehydrogenases may utilize NAD(+) (EC 1.3.1.43), NADP(+) (EC 1.3.1.78), or both (EC 1.3.1.79).
  • NADP(+)-dependent enzymes usually predominate in higher plants.
  • The enzyme from the cyanobacterium Synechocystis sp. PCC 6803 and the TyrAAT1 isoform of the plant Arabidopsis thaliana cannot use prephenate as a substrate, while the Arabidopsis isoform TyrAAT2 can use it very poorly.
Cross-references
BRENDA1.3.1.78
EC2PDB1.3.1.78
ExplorEnz1.3.1.78
PRIAM enzyme-specific profiles1.3.1.78
KEGG Ligand Database for Enzyme Nomenclature1.3.1.78
IUBMB Enzyme Nomenclature1.3.1.78
IntEnz1.3.1.78
MEDLINEFind literature relating to 1.3.1.78
MetaCyc1.3.1.78
Rhea expert-curated reactions1.3.1.78
UniProtKB/Swiss-Prot
Q944B6, TYRA1_ARATH;  Q9LMR3, TYRA2_ARATH;  

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