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ENZYME entry: EC 1.3.1.84

Accepted Name
Acrylyl-CoA reductase (NADPH).
Reaction catalysed
Propanoyl-CoA + NADP(+) <=> acrylyl-CoA + NADPH
Cofactor(s)
Zn(2+).
Comment(s)
  • Catalyzes a step in the 3-hydroxypropanoate/4-hydroxybutyrate cycle, an autotrophic CO(2) fixation pathway found in some thermoacidophilic archaea.
  • The reaction is catalyzed in the opposite direction to that shown.
  • The enzyme from Sulfolobus tokodaii does not act on either NADH or crotonyl-CoA.
  • Different from EC 1.3.1.8, which acts only on enoyl-CoA derivatives of carbon chain length 4 to 16.
Cross-references
PROSITEPDOC00058
BRENDA1.3.1.84
EC2PDB1.3.1.84
ExplorEnz1.3.1.84
PRIAM enzyme-specific profiles1.3.1.84
KEGG Ligand Database for Enzyme Nomenclature1.3.1.84
IUBMB Enzyme Nomenclature1.3.1.84
IntEnz1.3.1.84
MEDLINEFind literature relating to 1.3.1.84
MetaCyc1.3.1.84
UniProtKB/Swiss-Prot
A4YGN2, ACAR_METS5;  Q975C8, ACAR_SULTO;  P26646, ACUI_ECOLI;  
Q3J6K9, ACUI_RHOS4;  Q5LS56, ACUI_RUEPO;  

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