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ENZYME

ENZYME entry: EC 1.3.1.94

Accepted Name
polyprenal reductase
Alternative Name(s)
polyprenol reductase
Reaction catalysed
a di-trans,poly-cis-dolichal + NADP(+) = a di-trans,poly-cis-polyprenal + H(+) + NADPH
Comment(s)
  • The enzyme, isolated from human fetal brain tissue but present in all eukaryotes, catalyzes the reduction of the terminal double bond next to the alcohol group.
  • In mammalian cells dolichols are predominantly 18-21 isoprene units in length.
Cross-references
BRENDA1.3.1.94
EC2PDB1.3.1.94
ExplorEnz1.3.1.94
PRIAM enzyme-specific profiles1.3.1.94
KEGG Ligand Database for Enzyme Nomenclature1.3.1.94
IUBMB Enzyme Nomenclature1.3.1.94
IntEnz1.3.1.94
MEDLINEFind literature relating to 1.3.1.94
MetaCyc1.3.1.94
Rhea expert-curated reactions1.3.1.94
UniProtKB/Swiss-Prot
P40526, DFG10_YEASTQ9CAH5, PPRD1_ARATHA2XWN6, PPRD1_ORYSI
Q7XUH5, PPRD1_ORYSJQ9SI62, PPRD2_ARATHB8B6G5, PPRD2_ORYSI
Q7F0Q2, PPRD2_ORYSJD2HBV9, SR5A3_AILMEA8X8R3, SR5A3_CAEBR
Q17428, SR5A3_CAEELQ5RIU9, SR5A3_DANREQ9VLP9, SR5A3_DROME
Q9H8P0, SR5A3_HUMANC7T2J9, SR5A3_MESAUQ9WUP4, SR5A3_MOUSE
Q5RJM1, SR5A3_RATQ8AVI9, SR5A3_XENLAQ0P4J9, SR5A3_XENTR

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