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ENZYME entry: EC 1.3.1.99

Accepted Name
Iridoid synthase.
Reaction catalysed
(6E)-8-oxogeranial + NAD(P)H <=> cis-trans-nepetalactol + NAD(P)(+)
Comment(s)
  • Isolated from the plant Catharanthus roseus.
  • The reaction may involve cyclization via a Diels-Alder or Michael reaction.
  • Iridoids are involved in the biosynthesis of many indole alkaloids.
  • The cyclic hemiacetal is readily hydrolyzed to the corresponding dial.
Cross-references
BRENDA1.3.1.99
EC2PDB1.3.1.99
ExplorEnz1.3.1.99
PRIAM enzyme-specific profiles1.3.1.99
KEGG Ligand Database for Enzyme Nomenclature1.3.1.99
IUBMB Enzyme Nomenclature1.3.1.99
IntEnz1.3.1.99
MEDLINEFind literature relating to 1.3.1.99
MetaCyc1.3.1.99
UniProtKB/Swiss-Prot
A0A1C9CX56, CYC1_CAMAC;  A0A1C9CX66, CYC2_CAMAC;  K7WDL7, IRIS_CATRO;  

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