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ENZYME

ENZYME entry: EC 1.3.8.6

PURL: https://purl.expasy.org/enzyme/EC/1.3.8.6
Accepted Name
glutaryl-CoA dehydrogenase (ETF)
Alternative Name(s)
glutaryl-CoA dehydrogenase
Reaction catalysed
glutaryl-CoA + oxidized [electron-transfer flavoprotein] + 2 H(+) = (2E)-butenoyl-CoA + reduced [electron-transfer flavoprotein] + CO2
Comment(s)
  • The enzyme catalyzes the oxidation of glutaryl-CoA to glutaconyl-CoA (which remains bound to the enzyme), and the decarboxylation of the latter to crotonyl-CoA (cf. EC 7.2.4.5).
  • FAD is the electron acceptor in the oxidation of the substrate, and its reoxidation by electron-transfer flavoprotein completes the catalytic cycle.
  • The anaerobic, sulfate-reducing bacterium Desulfococcus multivorans contains two glutaryl-CoA dehydrogenases: a decarboxylating enzyme (this entry), and a non-decarboxylating enzyme that only catalyzes the oxidation to glutaconyl-CoA (EC 1.3.99.32).
  • Formerly EC 1.3.99.7.
Cross-references
BRENDA1.3.8.6
EC2PDB1.3.8.6
ExplorEnz1.3.8.6
KEGG Ligand Database for Enzyme Nomenclature1.3.8.6
IUBMB Enzyme Nomenclature1.3.8.6
MEDLINEFind literature relating to 1.3.8.6
MetaCyc1.3.8.6
Rhea expert-curated reactions1.3.8.6
UniProtKB/Swiss-Prot
Q2KHZ9, GCDH_BOVINQ20772, GCDH_CAEELQ54R47, GCDH_DICDI
A0AAD6NFV5, GCDH_DREDAQ92947, GCDH_HUMANQ8HXX8, GCDH_MACFA
Q60759, GCDH_MOUSEP81140, GCDH_PIG

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