ENZYME entry: EC 1.3.8.6
Accepted Name |
Glutaryl-CoA dehydrogenase (ETF).
|
Alternative Name(s) |
Glutaryl-CoA dehydrogenase. |
Reaction catalysed |
Glutaryl-CoA + electron-transfer flavoprotein <=> crotonyl-CoA + CO(2) + reduced electron-transfer flavoprotein |
Cofactor(s) |
FAD.
|
Comment(s) |
- The enzyme catalyzes the oxidation of glutaryl-CoA to glutaconyl-CoA
(which remains bound to the enzyme), and the decarboxylation of the
latter to crotonyl-CoA (cf. EC 7.2.4.5).
- FAD is the electron acceptor in the oxidation of the substrate,
and its reoxidation by electron-transfer flavoprotein completes the
catalytic cycle.
- The anaerobic, sulfate-reducing bacterium Desulfococcus multivorans
contains two glutaryl-CoA dehydrogenases: a decarboxylating enzyme
(this entry), and a non-decarboxylating enzyme that only catalyzes
the oxidation to glutaconyl-CoA (EC 1.3.99.32).
- Formerly EC 1.3.99.7.
|
Cross-references |
PROSITE | PDOC00070 |
BRENDA | 1.3.8.6 |
EC2PDB | 1.3.8.6 |
ExplorEnz | 1.3.8.6 |
PRIAM enzyme-specific profiles | 1.3.8.6 |
KEGG Ligand Database for Enzyme Nomenclature | 1.3.8.6 |
IUBMB Enzyme Nomenclature | 1.3.8.6 |
IntEnz | 1.3.8.6 |
MEDLINE | Find literature relating to 1.3.8.6 |
MetaCyc | 1.3.8.6 |
Rhea expert-curated reactions | 1.3.8.6 |
UniProtKB/Swiss-Prot |
|
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