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ENZYME entry: EC 7.2.4.5

Accepted Name
Glutaconyl-CoA decarboxylase.
Alternative Name(s)
4-carboxybut-2-enoyl-CoA carboxy-lyase.
Glutaconyl coenzyme A decarboxylase.
Pent-2-enoyl-CoA carboxy-lyase.
Reaction catalysed
4-carboxybut-2-enoyl-CoA + Na(+)(Side 1) <=> but-2-enoyl-CoA + CO(2) + Na(+)(Side 2)
Cofactor(s)
Biotin.
Comment(s)
  • The enzyme from the bacterium Acidaminococcus fermentans is a biotinyl-protein, requires Na(+), and acts as a sodium pump.
  • Prior to the Na(+)-dependent decarboxylation, the carboxylate is transferred to biotin in a Na(+)-independent manner.
  • The conserved lysine, to which biotin forms an amide bond, is located 34 amino acids before the C-terminus, flanked on both sides by two methionine residues, which are conserved in every biotin-dependent enzyme.
Cross-references
PROSITEPDOC00167 ; PDOC50980
BRENDA7.2.4.5
EC2PDB7.2.4.5
ExplorEnz7.2.4.5
PRIAM enzyme-specific profiles7.2.4.5
KEGG Ligand Database for Enzyme Nomenclature7.2.4.5
IUBMB Enzyme Nomenclature7.2.4.5
IntEnz7.2.4.5
MEDLINEFind literature relating to 7.2.4.5
MetaCyc7.2.4.5
UniProtKB/Swiss-Prot
Q06700, GCDA_ACIFV;  Q9ZAA6, GCDB_ACIFV;  Q9ZAA7, GCDC_ACIFV;  
Q9ZAA8, GCDD_ACIFV;  

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