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ENZYME

ENZYME entry: EC 7.2.4.5

PURL: https://purl.expasy.org/enzyme/EC/7.2.4.5
Accepted Name
glutaconyl-CoA decarboxylase
Alternative Name(s)
4-carboxybut-2-enoyl-CoA carboxy-lyase
glutaconyl coenzyme A decarboxylase
pent-2-enoyl-CoA carboxy-lyase
Reaction catalysed
(2E)-glutaconyl-CoA + Na(+)(in) + H(+) = (2E)-butenoyl-CoA + Na(+)(out) + CO2
Comment(s)
  • The enzyme from the bacterium Acidaminococcus fermentans is a biotinyl-protein, requires Na(+), and acts as a sodium pump.
  • Prior to the Na(+)-dependent decarboxylation, the carboxylate is transferred to biotin in a Na(+)-independent manner.
  • The conserved lysine, to which biotin forms an amide bond, is located 34 amino acids before the C-terminus, flanked on both sides by two methionine residues, which are conserved in every biotin-dependent enzyme.
  • Formerly EC 4.1.1.70.
Cross-references
BRENDA7.2.4.5
EC2PDB7.2.4.5
ExplorEnz7.2.4.5
KEGG Ligand Database for Enzyme Nomenclature7.2.4.5
IUBMB Enzyme Nomenclature7.2.4.5
MEDLINEFind literature relating to 7.2.4.5
MetaCyc7.2.4.5
Rhea expert-curated reactions7.2.4.5
UniProtKB/Swiss-Prot
Q06700, GCDA_ACIFVQ9ZAA6, GCDB_ACIFVQ9ZAA7, GCDC_ACIFV
Q9ZAA8, GCDD_ACIFV

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 7.2.4.-
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