ENZYME entry: EC 1.3.98.7

PURL: https://purl.expasy.org/enzyme/EC/1.3.98.7

Accepted Name

[mycofactocin precursor peptide]-tyrosine decarboxylase

Reaction catalysed

[mycofactocin precursor peptide]-C-terminal glycyl-L-valyl-L-tyrosine + S-adenosyl-L-methionine = [mycofactocin precursor peptide]-C-terminal glycyl-N-{[2-(4-hydroxyphenyl)ethenyl]-3-methylbutanamide} + 5'-deoxyadenosine + L-methionine + CO2

Comment(s)

This is a bifunctional radical AdoMet (radical SAM) enzyme that catalyzes the first two steps in the biosynthesis of the enzyme cofactor mycofactocin.
Activity requires the presence of the MftB chaperone.
The other activity of the enzyme is EC 4.1.99.26.

Cross-references

BRENDA

1.3.98.7

EC2PDB

1.3.98.7

ExplorEnz

1.3.98.7

KEGG Ligand Database for Enzyme Nomenclature

1.3.98.7

IUBMB Enzyme Nomenclature

1.3.98.7

MEDLINE

Find literature relating to 1.3.98.7

MetaCyc

1.3.98.7

Rhea expert-curated reactions

1.3.98.7

UniProtKB/Swiss-Prot

A0QSB8, MFTC_MYCS2	P9WJ78, MFTC_MYCTO	P9WJ79, MFTC_MYCTU
A0PM49, MFTC_MYCUA

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