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ENZYME

ENZYME entry: EC 4.1.99.26

PURL: https://purl.expasy.org/enzyme/EC/4.1.99.26
Accepted Name
3-amino-5-[(4-hydroxyphenyl)methyl]-4,4-dimethylpyrrolidin-2-one synthase
Reaction catalysed
[mycofactocin precursor peptide]-C-terminal glycyl-N-{[2-(4-hydroxyphenyl)ethenyl]-3-methylbutanamide} + AH2 + S-adenosyl-L-methionine = [mycofactocin precursor peptide]-C-terminal glycyl-N-{5-[(4-hydroxyphenyl)methyl]-4,4-dimethyl-2-oxopyrrolidin-3-yl}acetamide + 5'-deoxyadenosine + L-methionine + A + H(+)
Comment(s)
  • This is a bifunctional radical AdoMet (radical SAM) enzyme that catalyzes the first two steps in the biosynthesis of the enzyme cofactor mycofactocin.
  • Activity requires the presence of the MftB chaperone.
  • The reaction occurs in the right-to-left direction.
  • The other activity of the enzyme is EC 1.3.98.7.
Cross-references
BRENDA4.1.99.26
EC2PDB4.1.99.26
ExplorEnz4.1.99.26
KEGG Ligand Database for Enzyme Nomenclature4.1.99.26
IUBMB Enzyme Nomenclature4.1.99.26
MEDLINEFind literature relating to 4.1.99.26
MetaCyc4.1.99.26
Rhea expert-curated reactions4.1.99.26
UniProtKB/Swiss-Prot
A0QSB8, MFTC_MYCS2P9WJ78, MFTC_MYCTOP9WJ79, MFTC_MYCTU
A0PM49, MFTC_MYCUA

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