ENZYME entry: EC 1.3.99.36
| Accepted Name |
|---|
| Cypemycin cysteine dehydrogenase (decarboxylating).
|
| Alternative Name(s) |
|---|
| Cypemycin decarboxylase. |
| Reaction catalysed |
|---|
| Cypemycin(1-18)-L-Cys-L-Leu-L-Val-L-Cys + acceptor <=> C(3,19),S(21)-cypemycin(1-18)-L-Ala-L-Leu-N-thioethenyl-L-valinamide + CO(2) + H(2)S + reduced acceptor |
| Comment(s) |
|---|
- Cypemycin, isolated from the bacterium Streptomyces sp. OH-4156, is a
peptide antibiotic, member of the linaridins, a class of
posttranslationally modified ribosomally synthesized peptides.
- The enzyme decarboxylates and reduces the C-terminal L-cysteine
residue, producing a reactive ethenethiol group that reacts with a
dethiolated cysteine upstream to form an aminovinyl-methyl-cysteine
loop that is important for the antibiotic activity of the mature
peptide.
- Formerly EC 1.3.99.n3.
|
| Cross-references |
|---|
| BRENDA | 1.3.99.36 |
| EC2PDB | 1.3.99.36 |
| ExplorEnz | 1.3.99.36 |
| PRIAM enzyme-specific profiles | 1.3.99.36 |
| KEGG Ligand Database for Enzyme Nomenclature | 1.3.99.36 |
| IUBMB Enzyme Nomenclature | 1.3.99.36 |
| IntEnz | 1.3.99.36 |
| MEDLINE | Find literature relating to 1.3.99.36 |
| MetaCyc | 1.3.99.36 |
| Rhea expert-curated reactions | 1.3.99.36 |
| UniProtKB/Swiss-Prot |
|
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