ENZYME

ENZYME entry: EC 1.3.99.36

Accepted Name

Cypemycin cysteine dehydrogenase (decarboxylating).

Alternative Name(s)

Cypemycin decarboxylase.

Reaction catalysed

Cypemycin(1-18)-L-Cys-L-Leu-L-Val-L-Cys + acceptor <=> C(3,19),S(21)-cypemycin(1-18)-L-Ala-L-Leu-N-thioethenyl-L-valinamide + CO(2) + H(2)S + reduced acceptor

Comment(s)

Cypemycin, isolated from the bacterium Streptomyces sp. OH-4156, is a peptide antibiotic, member of the linaridins, a class of posttranslationally modified ribosomally synthesized peptides.
The enzyme decarboxylates and reduces the C-terminal L-cysteine residue, producing a reactive ethenethiol group that reacts with a dethiolated cysteine upstream to form an aminovinyl-methyl-cysteine loop that is important for the antibiotic activity of the mature peptide.
Formerly EC 1.3.99.n3.

Cross-references

BRENDA

1.3.99.36

EC2PDB

1.3.99.36

ExplorEnz

1.3.99.36

PRIAM enzyme-specific profiles

1.3.99.36

KEGG Ligand Database for Enzyme Nomenclature

1.3.99.36

IUBMB Enzyme Nomenclature