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ENZYME

ENZYME entry: EC 1.3.99.36

Accepted Name
cypemycin cysteine dehydrogenase (decarboxylating)
Alternative Name(s)
cypemycin decarboxylase
Reaction catalysed
[cypemycin](1-18)-L-Cys-L-Leu-L-Val-L-Cys + A <=> AH2 + C(3,19),S(21)-[cypemycin](1-18)-L-Ala-L-Leu-N-thioethenyl-L-valinamide + CO2 + hydrogen sulfide
Comment(s)
  • Cypemycin, isolated from the bacterium Streptomyces sp. OH-4156, is a peptide antibiotic, member of the linaridins, a class of post- translationally modified ribosomally synthesized peptides.
  • The enzyme decarboxylates and reduces the C-terminal L-cysteine residue, producing a reactive ethenethiol group that reacts with a dethiolated cysteine upstream to form an aminovinyl-methyl-cysteine loop that is important for the antibiotic activity of the mature peptide.
  • Formerly EC 1.3.99.n3.
Cross-references
BRENDA1.3.99.36
EC2PDB1.3.99.36
ExplorEnz1.3.99.36
PRIAM enzyme-specific profiles1.3.99.36
KEGG Ligand Database for Enzyme Nomenclature1.3.99.36
IUBMB Enzyme Nomenclature1.3.99.36
IntEnz1.3.99.36
MEDLINEFind literature relating to 1.3.99.36
MetaCyc1.3.99.36
Rhea expert-curated reactions1.3.99.36
UniProtKB/Swiss-Prot
E5KIB9, CYPD_STRSQ

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