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ENZYME entry: EC 1.4.3.21

Accepted Name
primary-amine oxidase.
Alternative Name(s)
amine oxidase.
amine oxidase (copper-containing).
benzylamine oxidase.
CAO.
copper amine oxidase.
Reaction catalysed
an aliphatic amine + H2O + O2 <=> an aldehyde + H2O2 + NH4(+)
Comment(s)
  • A group of enzymes that oxidize primary monoamines but have little or no activity toward diamines, such as histamine, or toward secondary and tertiary amines.
  • They are copper quinoproteins (2,4,5-trihydroxyphenylalanine quinone) and, unlike EC 1.4.3.4, are sensitive to inhibition by carbonyl-group reagents, such as semicarbazide.
  • In some mammalian tissues the enzyme also functions as a vascular- adhesion protein (VAP-1).
  • Formerly EC 1.4.3.6.
Cross-references
BRENDA1.4.3.21
EC2PDB1.4.3.21
ExplorEnz1.4.3.21
PRIAM enzyme-specific profiles1.4.3.21
KEGG Ligand Database for Enzyme Nomenclature1.4.3.21
IUBMB Enzyme Nomenclature1.4.3.21
IntEnz1.4.3.21
MEDLINEFind literature relating to 1.4.3.21
MetaCyc1.4.3.21
Rhea expert-curated reactions1.4.3.21
UniProtKB/Swiss-Prot
Q07121, AMO1_ARTS1;  P0DO00, AMO2_ARATH;  Q07123, AMO2_ARTS1;  
P46883, AMO_ECOLI;  P49250, AMO_KLEAE;  P80695, AMO_KLEOK;  
P49252, AMO_LENCU;  Q43077, AMO_PEA;  P12807, AMO_PICAN;  
O23349, AO1_ARATH;  O75106, AOC2_HUMAN;  Q812C9, AOC2_MOUSE;  
Q9TTK6, AOC3_BOVIN;  Q16853, AOC3_HUMAN;  O70423, AOC3_MOUSE;  
Q5R9I0, AOC3_PONAB;  O08590, AOC3_RAT;  Q29437, AOCX_BOVIN;  
O46406, AOCY_BOVIN;  P21398, AOFA_BOVIN;  P58027, AOFA_CANLF;  
Q5NU32, AOFA_HORSE;  P21397, AOFA_HUMAN;  Q64133, AOFA_MOUSE;  
Q6Q2J0, AOFA_PIG;  Q5RE60, AOFA_PONAB;  P21396, AOFA_RAT;  
O18851, AOFA_SHEEP;  P56560, AOFB_BOVIN;  Q7YRB7, AOFB_CANLF;  
P58028, AOFB_CAVPO;  P27338, AOFB_HUMAN;  Q8BW75, AOFB_MOUSE;  
Q6PLK3, AOFB_PIG;  Q5RE98, AOFB_PONAB;  P19643, AOFB_RAT;  
Q6NSN2, AOF_DANRE;  Q9P7F2, CAO1_SCHPO;  O42890, CAO2_SCHPO;  
F4IAX0, CAOA2_ARATH;  F4IAX1, CAOA3_ARATH;  Q8H1H9, CAOG1_ARATH;  
Q9M2B9, CAOG2_ARATH;  Q8L866, CUAOZ_ARATH;  A0A1S3XSG2, DAO1_TOBAC;  
A0A1S4BDC4, MPO1_TOBAC;  P46881, PAOX_ARTGO;  

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