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ENZYME

ENZYME entry: EC 1.4.3.21

Accepted Name
primary-amine oxidase
Alternative Name(s)
amine oxidase
amine oxidase (copper-containing)
benzylamine oxidase
CAO
copper amine oxidase
Reaction catalysed
an aliphatic amine + H2O + O2 <=> an aldehyde + H2O2 + NH4(+)
Comment(s)
  • A group of enzymes that oxidize primary monoamines but have little or no activity toward diamines, such as histamine, or toward secondary and tertiary amines.
  • They are copper quinoproteins (2,4,5-trihydroxyphenylalanine quinone) and, unlike EC 1.4.3.4, are sensitive to inhibition by carbonyl-group reagents, such as semicarbazide.
  • In some mammalian tissues the enzyme also functions as a vascular- adhesion protein (VAP-1).
  • Formerly EC 1.4.3.6.
Cross-references
BRENDA1.4.3.21
EC2PDB1.4.3.21
ExplorEnz1.4.3.21
PRIAM enzyme-specific profiles1.4.3.21
KEGG Ligand Database for Enzyme Nomenclature1.4.3.21
IUBMB Enzyme Nomenclature1.4.3.21
IntEnz1.4.3.21
MEDLINEFind literature relating to 1.4.3.21
MetaCyc1.4.3.21
Rhea expert-curated reactions1.4.3.21
UniProtKB/Swiss-Prot
Q07121, AMO1_ARTS1P0DO00, AMO2_ARATHQ07123, AMO2_ARTS1
P46883, AMO_ECOLIP49250, AMO_KLEAEP80695, AMO_KLEOK
P49252, AMO_LENCUQ43077, AMO_PEAP12807, AMO_PICAN
O23349, AO1_ARATHO75106, AOC2_HUMANQ812C9, AOC2_MOUSE
Q9TTK6, AOC3_BOVINQ16853, AOC3_HUMANO70423, AOC3_MOUSE
Q5R9I0, AOC3_PONABO08590, AOC3_RATQ29437, AOCX_BOVIN
O46406, AOCY_BOVINP21398, AOFA_BOVINP58027, AOFA_CANLF
Q5NU32, AOFA_HORSEP21397, AOFA_HUMANQ64133, AOFA_MOUSE
Q6Q2J0, AOFA_PIGQ5RE60, AOFA_PONABP21396, AOFA_RAT
O18851, AOFA_SHEEPP56560, AOFB_BOVINQ7YRB7, AOFB_CANLF
P58028, AOFB_CAVPOP27338, AOFB_HUMANQ8BW75, AOFB_MOUSE
Q6PLK3, AOFB_PIGQ5RE98, AOFB_PONABP19643, AOFB_RAT
Q6NSN2, AOF_DANREQ9P7F2, CAO1_SCHPOO42890, CAO2_SCHPO
F4IAX0, CAOA2_ARATHF4IAX1, CAOA3_ARATHQ8H1H9, CAOG1_ARATH
Q9M2B9, CAOG2_ARATHQ8L866, CUAOZ_ARATHA0A1S3XSG2, DAO1_TOBAC
A0A1S4BDC4, MPO1_TOBACP46881, PAOX_ARTGO

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.4.3.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.4.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.-.-.-