ENZYME entry: EC 1.4.3.4
Accepted Name |
monoamine oxidase.
|
Alternative Name(s) |
adrenaline oxidase. |
amine oxidase. |
amine oxidase (flavin-containing). |
tyraminase. |
tyramine oxidase. |
Reaction catalysed |
a secondary aliphatic amine + H2O + O2 <=> a primary amine + an aldehyde + H2O2 |
Comment(s) |
- Catalyzes the oxidative deamination of neurotransmitters and biogenic
amines.
- Acts on primary amines, and also on some secondary and tertiary
amines.
- It differs from EC 1.4.3.21, as it can oxidize secondary and tertiary
amines but not methylamine.
- Inhibited by acetylenic compounds such as chlorgyline, 1-deprenyl and
pargyline but, unlike EC 1.4.3.21 and EC 1.4.3.22, it is not
inhibited by semicarbazide.
- Formerly EC 1.4.3.9.
|
Cross-references |
BRENDA | 1.4.3.4 |
EC2PDB | 1.4.3.4 |
ExplorEnz | 1.4.3.4 |
PRIAM enzyme-specific profiles | 1.4.3.4 |
KEGG Ligand Database for Enzyme Nomenclature | 1.4.3.4 |
IUBMB Enzyme Nomenclature | 1.4.3.4 |
IntEnz | 1.4.3.4 |
MEDLINE | Find literature relating to 1.4.3.4 |
MetaCyc | 1.4.3.4 |
Rhea expert-curated reactions | 1.4.3.4 |
UniProtKB/Swiss-Prot |
P21398, AOFA_BOVIN; | P58027, AOFA_CANLF; | Q54IT3, AOFA_DICDI; |
Q5NU32, AOFA_HORSE; | P21397, AOFA_HUMAN; | Q64133, AOFA_MOUSE; |
Q6Q2J0, AOFA_PIG; | Q5RE60, AOFA_PONAB; | P21396, AOFA_RAT; |
O18851, AOFA_SHEEP; | P56560, AOFB_BOVIN; | Q7YRB7, AOFB_CANLF; |
P58028, AOFB_CAVPO; | Q556K3, AOFB_DICDI; | P27338, AOFB_HUMAN; |
Q8BW75, AOFB_MOUSE; | Q6PLK3, AOFB_PIG; | Q5RE98, AOFB_PONAB; |
P19643, AOFB_RAT; | Q556K4, AOFC_DICDI; | P46882, AOFN_ASPNG; |
Q6NSN2, AOF_DANRE; | P49253, AOF_ONCMY; |
|
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ENZYME /
UniProtKB/Swiss-Prot entries corresponding to 1.4.3.-
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