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ENZYME entry: EC 1.4.3.4

Accepted Name
Monoamine oxidase.
Alternative Name(s)
Adrenaline oxidase.
Amine oxidase.
Amine oxidase (flavin-containing).
Tyraminase.
Tyramine oxidase.
Reaction catalysed
RCH(2)NHR' + H(2)O + O(2) <=> RCHO + R'NH(2) + H(2)O(2)
Cofactor(s)
FAD.
Comment(s)
  • Catalyzes the oxidative deamination of neurotransmitters and biogenic amines.
  • Acts on primary amines, and also on some secondary and tertiary amines.
  • It differs from EC 1.4.3.21, as it can oxidize secondary and tertiary amines but not methylamine.
  • Inhibited by acetylenic compounds such as chlorgyline, 1-deprenyl and pargyline but, unlike EC 1.4.3.21 and EC 1.4.3.22, it is not inhibited by semicarbazide.
  • Formerly EC 1.4.3.9.
Cross-references
BRENDA1.4.3.4
EC2PDB1.4.3.4
ExplorEnz1.4.3.4
PRIAM enzyme-specific profiles1.4.3.4
KEGG Ligand Database for Enzyme Nomenclature1.4.3.4
IUBMB Enzyme Nomenclature1.4.3.4
IntEnz1.4.3.4
MEDLINEFind literature relating to 1.4.3.4
MetaCyc1.4.3.4
Rhea expert-curated reactions1.4.3.4
UniProtKB/Swiss-Prot
P21398, AOFA_BOVIN;  P58027, AOFA_CANLF;  Q54IT3, AOFA_DICDI;  
Q5NU32, AOFA_HORSE;  P21397, AOFA_HUMAN;  Q64133, AOFA_MOUSE;  
Q6Q2J0, AOFA_PIG;  Q5RE60, AOFA_PONAB;  P21396, AOFA_RAT;  
O18851, AOFA_SHEEP;  P56560, AOFB_BOVIN;  Q7YRB7, AOFB_CANLF;  
P58028, AOFB_CAVPO;  Q556K3, AOFB_DICDI;  P27338, AOFB_HUMAN;  
Q8BW75, AOFB_MOUSE;  Q6PLK3, AOFB_PIG;  Q5RE98, AOFB_PONAB;  
P19643, AOFB_RAT;  Q556K4, AOFC_DICDI;  P46882, AOFN_ASPNG;  
Q6NSN2, AOF_DANRE;  P49253, AOF_ONCMY;  

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.4.3.-
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