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ENZYME

ENZYME entry: EC 1.4.3.4

Accepted Name
monoamine oxidase
Alternative Name(s)
adrenaline oxidase
amine oxidase
amine oxidase (flavin-containing)
tyraminase
tyramine oxidase
Reaction catalysed
a secondary aliphatic amine + H2O + O2 <=> a primary amine + an aldehyde + H2O2
Comment(s)
  • Catalyzes the oxidative deamination of neurotransmitters and biogenic amines.
  • Acts on primary amines, and also on some secondary and tertiary amines.
  • It differs from EC 1.4.3.21, as it can oxidize secondary and tertiary amines but not methylamine.
  • Inhibited by acetylenic compounds such as chlorgyline, 1-deprenyl and pargyline but, unlike EC 1.4.3.21 and EC 1.4.3.22, it is not inhibited by semicarbazide.
  • Formerly EC 1.4.3.9.
Cross-references
BRENDA1.4.3.4
EC2PDB1.4.3.4
ExplorEnz1.4.3.4
PRIAM enzyme-specific profiles1.4.3.4
KEGG Ligand Database for Enzyme Nomenclature1.4.3.4
IUBMB Enzyme Nomenclature1.4.3.4
IntEnz1.4.3.4
MEDLINEFind literature relating to 1.4.3.4
MetaCyc1.4.3.4
Rhea expert-curated reactions1.4.3.4
UniProtKB/Swiss-Prot
P21398, AOFA_BOVINP58027, AOFA_CANLFQ54IT3, AOFA_DICDI
Q5NU32, AOFA_HORSEP21397, AOFA_HUMANQ64133, AOFA_MOUSE
Q6Q2J0, AOFA_PIGQ5RE60, AOFA_PONABP21396, AOFA_RAT
O18851, AOFA_SHEEPP56560, AOFB_BOVINQ7YRB7, AOFB_CANLF
P58028, AOFB_CAVPOQ556K3, AOFB_DICDIP27338, AOFB_HUMAN
Q8BW75, AOFB_MOUSEQ6PLK3, AOFB_PIGQ5RE98, AOFB_PONAB
P19643, AOFB_RATQ556K4, AOFC_DICDIP46882, AOFN_ASPNG
Q6NSN2, AOF_DANREP49253, AOF_ONCMY

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.4.3.-
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