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ENZYME

ENZYME entry: EC 1.5.1.1

PURL: https://purl.expasy.org/enzyme/EC/1.5.1.1
Accepted Name
1-piperideine-2-carboxylate/1-pyrroline-2-carboxylate reductase [NAD(P)H]
Alternative Name(s)
pyrroline-2-carboxylate reductase
Reaction catalysed
  • L-pipecolate + NADP(+) = Delta(1)-piperideine-2-carboxylate + NADPH + H(+)
  • L-pipecolate + NAD(+) = Delta(1)-piperideine-2-carboxylate + NADH + H(+)
  • L-proline + NADP(+) = 1-pyrroline-2-carboxylate + NADPH + H(+)
  • L-proline + NAD(+) = 1-pyrroline-2-carboxylate + NADH + H(+)
Comment(s)
  • The enzymes, characterized from the bacterium Azospirillum brasilense, is involved in trans-3-hydroxy-L-proline metabolism.
  • In contrast to EC 1.5.1.21, which is specific for NADPH, this enzyme shows similar activity with NADPH and NADH.
Cross-references
Rhea expert-curated reactions1.5.1.1
ExplorEnz1.5.1.1
IUBMB Enzyme Nomenclature1.5.1.1
UniProtKB/Swiss-Prot
Q2KHX6, CRYM_BOVINQ14894, CRYM_HUMANQ28488, CRYM_MACFL
O54983, CRYM_MOUSEQ9QYU4, CRYM_RATV5YW53, PY2CR_AZOBR
Q9FLY0, SARD4_ARATH
BRENDA1.5.1.1
MetaCyc1.5.1.1
KEGG Ligand Database for Enzyme Nomenclature1.5.1.1
MEDLINEFind literature relating to 1.5.1.1

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