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ENZYME entry: EC 1.5.1.1

Accepted Name
1-piperideine-2-carboxylate/1-pyrroline-2-carboxylate reductase [NAD(P)H].
Alternative Name(s)
pyrroline-2-carboxylate reductase.
Reaction catalysed
  • L-pipecolate + NADP(+) <=> Delta(1)-piperideine-2-carboxylate + H(+) + NADPH
  • L-pipecolate + NAD(+) <=> Delta(1)-piperideine-2-carboxylate + H(+) + NADH
  • L-proline + NADP(+) <=> 1-pyrroline-2-carboxylate + H(+) + NADPH
  • L-proline + NAD(+) <=> 1-pyrroline-2-carboxylate + H(+) + NADH
Comment(s)
  • The enzymes, characterized from the bacterium Azospirillum brasilense, is involved in trans-3-hydroxy-L-proline metabolism.
  • In contrast to EC 1.5.1.21, which is specific for NADPH, this enzyme shows similar activity with NADPH and NADH.
Cross-references
BRENDA1.5.1.1
EC2PDB1.5.1.1
ExplorEnz1.5.1.1
PRIAM enzyme-specific profiles1.5.1.1
KEGG Ligand Database for Enzyme Nomenclature1.5.1.1
IUBMB Enzyme Nomenclature1.5.1.1
IntEnz1.5.1.1
MEDLINEFind literature relating to 1.5.1.1
MetaCyc1.5.1.1
Rhea expert-curated reactions1.5.1.1
UniProtKB/Swiss-Prot
V5YW53, PY2CR_AZOBR

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