ENZYME entry: EC 1.5.1.43

Accepted Name
Carboxynorspermidine synthase.
Alternative Name(s)
Carboxynorspermidine dehydrogenase.
Carboxyspermidine dehydrogenase.
Reaction catalysed
Carboxynorspermidine + H(2)O + NADP(+) <=> L-aspartate 4-semialdehyde + propane-1,3-diamine + NADPH Carboxyspermidine + H(2)O + NADP(+) <=> L-aspartate 4-semialdehyde + putrescine + NADPH
Comment(s)
The reaction takes place in the opposite direction. Part of a bacterial polyamine biosynthesis pathway. L-aspartate 4-semialdehyde and propane-1,3-diamine/putrescine form a Schiff base that is reduced to form carboxynorspermidine/carboxyspermidine, respectively. The enzyme from the bacterium Vibrio cholerae is essential for biofilm formation. The enzyme from Campylobacter jejuni only produces carboxyspermidine in vivo even though it also can produce carboxynorspermidine in vitro.
Cross-references
BRENDA	1.5.1.43
EC2PDB	1.5.1.43
ExplorEnz	1.5.1.43
PRIAM enzyme-specific profiles	1.5.1.43
KEGG Ligand Database for Enzyme Nomenclature	1.5.1.43
IUBMB Enzyme Nomenclature	1.5.1.43
IntEnz	1.5.1.43
MEDLINE	Find literature relating to 1.5.1.43
MetaCyc	1.5.1.43
UniProtKB/Swiss-Prot	P0DPE4, CANSD_VIBAX;   Q9KRL3, CANSD_VIBCH;

View entry in original ENZYME format
View entry in raw text format (no links)

All UniProtKB/Swiss-Prot entries referenced in this entry, with possibility to download in different formats, align etc.
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.5.1.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.5.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.-.-.-