A new class EC 7, Translocases, has been added to the EC list. It will be part of ENZYME from release 2018_10. Read more about EC 7 here.
ENZYME entry: EC 1.5.1.43
Accepted Name |
Carboxynorspermidine synthase.
|
Alternative Name(s) |
Carboxynorspermidine dehydrogenase. |
Carboxyspermidine dehydrogenase. |
Reaction catalysed |
- Carboxynorspermidine + H(2)O + NADP(+) <=> L-aspartate 4-semialdehyde + propane-1,3-diamine + NADPH
- Carboxyspermidine + H(2)O + NADP(+) <=> L-aspartate 4-semialdehyde + putrescine + NADPH
|
Comment(s) |
- The reaction takes place in the opposite direction.
- Part of a bacterial polyamine biosynthesis pathway.
- L-aspartate 4-semialdehyde and propane-1,3-diamine/putrescine form a
Schiff base that is reduced to form
carboxynorspermidine/carboxyspermidine, respectively.
- The enzyme from the bacterium Vibrio cholerae is essential for
biofilm formation.
- The enzyme from Campylobacter jejuni only produces carboxyspermidine
in vivo even though it also can produce carboxynorspermidine in
vitro.
|
Cross-references |
BRENDA | 1.5.1.43 |
EC2PDB | 1.5.1.43 |
ExplorEnz | 1.5.1.43 |
PRIAM enzyme-specific profiles | 1.5.1.43 |
KEGG Ligand Database for Enzyme Nomenclature | 1.5.1.43 |
IUBMB Enzyme Nomenclature | 1.5.1.43 |
IntEnz | 1.5.1.43 |
MEDLINE | Find literature relating to 1.5.1.43 |
MetaCyc | 1.5.1.43 |
UniProtKB/Swiss-Prot |
|
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ENZYME /
UniProtKB/Swiss-Prot entries corresponding to 1.5.1.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.5.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.-.-.-