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ENZYME entry: EC 1.5.1.43

Accepted Name
Carboxynorspermidine synthase.
Alternative Name(s)
Carboxynorspermidine dehydrogenase.
Carboxyspermidine dehydrogenase.
Reaction catalysed
  • Carboxynorspermidine + H(2)O + NADP(+) <=> L-aspartate 4-semialdehyde + propane-1,3-diamine + NADPH
  • Carboxyspermidine + H(2)O + NADP(+) <=> L-aspartate 4-semialdehyde + putrescine + NADPH
Comment(s)
  • The reaction takes place in the opposite direction.
  • Part of a bacterial polyamine biosynthesis pathway.
  • L-aspartate 4-semialdehyde and propane-1,3-diamine/putrescine form a Schiff base that is reduced to form carboxynorspermidine/carboxyspermidine, respectively.
  • The enzyme from the bacterium Vibrio cholerae is essential for biofilm formation.
  • The enzyme from Campylobacter jejuni only produces carboxyspermidine in vivo even though it also can produce carboxynorspermidine in vitro.
Cross-references
BRENDA1.5.1.43
EC2PDB1.5.1.43
ExplorEnz1.5.1.43
PRIAM enzyme-specific profiles1.5.1.43
KEGG Ligand Database for Enzyme Nomenclature1.5.1.43
IUBMB Enzyme Nomenclature1.5.1.43
IntEnz1.5.1.43
MEDLINEFind literature relating to 1.5.1.43
MetaCyc1.5.1.43
UniProtKB/Swiss-Prot
P0DPE4, CANSD_VIBAX;  Q9KRL3, CANSD_VIBCH;  

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