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ENZYME entry: EC 1.5.1.43

Accepted Name
carboxynorspermidine synthase.
Alternative Name(s)
carboxynorspermidine dehydrogenase.
carboxyspermidine dehydrogenase.
Reaction catalysed
  • carboxynorspermidine + H2O + NADP(+) <=> H(+) + L-aspartate 4-semialdehyde + NADPH + propane-1,3-diamine
  • carboxyspermidine + H2O + NADP(+) <=> H(+) + L-aspartate 4-semialdehyde + NADPH + putrescine
Comment(s)
  • The reaction takes place in the opposite direction.
  • Part of a bacterial polyamine biosynthesis pathway.
  • L-aspartate 4-semialdehyde and propane-1,3-diamine/putrescine form a Schiff base that is reduced to form carboxynorspermidine/carboxyspermidine, respectively.
  • The enzyme from the bacterium Vibrio cholerae is essential for biofilm formation.
  • The enzyme from Campylobacter jejuni only produces carboxyspermidine in vivo even though it also can produce carboxynorspermidine in vitro.
Cross-references
BRENDA1.5.1.43
EC2PDB1.5.1.43
ExplorEnz1.5.1.43
PRIAM enzyme-specific profiles1.5.1.43
KEGG Ligand Database for Enzyme Nomenclature1.5.1.43
IUBMB Enzyme Nomenclature1.5.1.43
IntEnz1.5.1.43
MEDLINEFind literature relating to 1.5.1.43
MetaCyc1.5.1.43
Rhea expert-curated reactions1.5.1.43
UniProtKB/Swiss-Prot
P0DPE4, CANSD_VIBAX;  Q9KRL3, CANSD_VIBCH;  

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.5.1.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.5.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.-.-.-