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A new class EC 7, Translocases, has been added to the EC list. It will be part of ENZYME from release 2018_10. Read more about EC 7 here.

ENZYME entry: EC

Accepted Name
Carboxynorspermidine synthase.
Alternative Name(s)
Carboxynorspermidine dehydrogenase.
Carboxyspermidine dehydrogenase.
Reaction catalysed
  • Carboxynorspermidine + H(2)O + NADP(+) <=> L-aspartate 4-semialdehyde + propane-1,3-diamine + NADPH
  • Carboxyspermidine + H(2)O + NADP(+) <=> L-aspartate 4-semialdehyde + putrescine + NADPH
  • The reaction takes place in the opposite direction.
  • Part of a bacterial polyamine biosynthesis pathway.
  • L-aspartate 4-semialdehyde and propane-1,3-diamine/putrescine form a Schiff base that is reduced to form carboxynorspermidine/carboxyspermidine, respectively.
  • The enzyme from the bacterium Vibrio cholerae is essential for biofilm formation.
  • The enzyme from Campylobacter jejuni only produces carboxyspermidine in vivo even though it also can produce carboxynorspermidine in vitro.
PRIAM enzyme-specific profiles1.5.1.43
KEGG Ligand Database for Enzyme Nomenclature1.5.1.43
IUBMB Enzyme Nomenclature1.5.1.43
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