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ENZYME

ENZYME entry: EC 1.5.1.49

PURL: https://purl.expasy.org/enzyme/EC/1.5.1.49
Accepted Name
1-pyrroline-2-carboxylate reductase [NAD(P)H]
Reaction catalysed
  • L-proline + NADP(+) = 1-pyrroline-2-carboxylate + NADPH + H(+)
  • L-proline + NAD(+) = 1-pyrroline-2-carboxylate + NADH + H(+)
Comment(s)
  • The enzyme from the bacterium Colwellia psychrerythraea is involved in trans-3-hydroxy-L-proline metabolism.
  • In contrast to EC 1.5.1.1 which shows similar activity with 1-piperideine-2-carboxylate and 1-pyrroline-2-carboxylate, this enzyme is specific for the latter.
  • While the enzyme is active with both NADH and NADPH, activity is higher with NADPH.
Cross-references
BRENDA1.5.1.49
EC2PDB1.5.1.49
ExplorEnz1.5.1.49
KEGG Ligand Database for Enzyme Nomenclature1.5.1.49
IUBMB Enzyme Nomenclature1.5.1.49
MEDLINEFind literature relating to 1.5.1.49
MetaCyc1.5.1.49
Rhea expert-curated reactions1.5.1.49
UniProtKB/Swiss-Prot
Q7CVK1, PY2CR_AGRFCD7A0Y0, PY2CR_ANCN5Q73CR9, PY2CR_BACC1
Q81HB0, PY2CR_BACCRQ63FA5, PY2CR_BACCZQ6HMS8, PY2CR_BACHK
Q485R8, PY2CR_COLP3A1B196, PY2CR_PARDPQ4KGT8, PY2CR_PSEF5
Q0B9S2, PYCR1_BURCMA9AKH1, PYCR1_BURM1Q0B953, PYCR2_BURCM
A9ALD3, PYCR2_BURM1

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.5.1.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.5.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.-.-.-