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A new class EC 7, Translocases, has been added to the EC list. It will be part of ENZYME from release 2018_10. Read more about EC 7 here.

ENZYME entry: EC 1.5.1.49

Accepted Name
1-pyrroline-2-carboxylate reductase (NAD(P)H).
Reaction catalysed
L-proline + NAD(P)(+) <=> 1-pyrroline-2-carboxylate + NAD(P)H
Comment(s)
  • The enzyme from the bacterium Colwellia psychrerythraea is involved in trans-3-hydroxy-L-proline metabolism.
  • In contrast to EC 1.5.1.1 which shows similar activity with 1-piperideine-2-carboxylate and 1-pyrroline-2-carboxylate, this enzyme is specific for the latter.
  • While the enzyme is active with both NADH and NADPH, activity is higher with NADPH.
Cross-references
BRENDA1.5.1.49
EC2PDB1.5.1.49
ExplorEnz1.5.1.49
PRIAM enzyme-specific profiles1.5.1.49
KEGG Ligand Database for Enzyme Nomenclature1.5.1.49
IUBMB Enzyme Nomenclature1.5.1.49
IntEnz1.5.1.49
MEDLINEFind literature relating to 1.5.1.49
MetaCyc1.5.1.49
UniProtKB/Swiss-Prot
Q7CVK1, PY2CR_AGRFC;  Q73CR9, PY2CR_BACC1;  Q81HB0, PY2CR_BACCR;  
Q63FA5, PY2CR_BACCZ;  Q6HMS8, PY2CR_BACHK;  Q485R8, PY2CR_COLP3;  
A1B196, PY2CR_PARDP;  Q4KGT8, PY2CR_PSEF5;  D7A0Y0, PY2CR_STAND;  
Q0B9S2, PYCR1_BURCM;  A9AKH1, PYCR1_BURM1;  Q0B953, PYCR2_BURCM;  
A9ALD3, PYCR2_BURM1;  

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.5.1.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.5.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.-.-.-