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ENZYME

ENZYME entry: EC 1.5.1.56

PURL: https://purl.expasy.org/enzyme/EC/1.5.1.56
Accepted Name
3,17-didehydrostemmadenine reductase
Reaction catalysed
17-dehydrostemmadenine + NADP(+) = 3,17-didehydrostemmadenine + NADPH
Comment(s)
  • The enzyme, characterized from the plant Catharanthus roseus (Madagascar periwinkle), participates in a biosynthetic pathway that leads to production of the bisindole alkaloid compounds vinblastine and vincristine, which are used as anticancer drugs.
  • Both the substrate and the product of the enzyme are unstable.
Cross-references
BRENDA1.5.1.56
EC2PDB1.5.1.56
ExplorEnz1.5.1.56
KEGG Ligand Database for Enzyme Nomenclature1.5.1.56
IUBMB Enzyme Nomenclature1.5.1.56
MEDLINEFind literature relating to 1.5.1.56
MetaCyc1.5.1.56
Rhea expert-curated reactions1.5.1.56
UniProtKB/Swiss-Prot
A0A2P1GIW4, REDX1_CATRO

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