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ENZYME

ENZYME entry: EC 1.5.3.24

Accepted Name
sarcosine oxidase (5,10-methylenetetrahydrofolate-forming)
Reaction catalysed
(6S)-5,6,7,8-tetrahydrofolate + O2 + sarcosine = (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + glycine + H2O2
Comment(s)
  • The enzyme, found in some bacterial species, is composed of four different subunits and two active sites connected by a large 'reaction chamber'.
  • An imine intermediate is transferred between the sites, eliminating the production of toxic formaldehyde.
  • The enzyme contains three cofactors: non-covalently bound FAD and NAD(+), and FMN that is covalently bound to a histidine residue.
  • In the absence of folate the enzyme catalyzes the reaction of EC 1.5.3.1.
Cross-references
BRENDA1.5.3.24
EC2PDB1.5.3.24
ExplorEnz1.5.3.24
PRIAM enzyme-specific profiles1.5.3.24
KEGG Ligand Database for Enzyme Nomenclature1.5.3.24
IUBMB Enzyme Nomenclature1.5.3.24
IntEnz1.5.3.24
MEDLINEFind literature relating to 1.5.3.24
MetaCyc1.5.3.24
Rhea expert-curated reactions1.5.3.24
UniProtKB/Swiss-Prot
Q9AGP1, TSOXA_ARTSPQ46337, TSOXA_CORS1Q50LF0, TSOXA_CORS9
O87386, TSOXA_RHIMEQ9AGP3, TSOXB_ARTSPP40875, TSOXB_CORS1
Q50LF2, TSOXB_CORS9O87388, TSOXB_RHIMEQ52671, TSOXB_RHOCB
Q9AGP2, TSOXD_ARTSPQ46336, TSOXD_CORS1Q50LF1, TSOXD_CORS9
O87387, TSOXD_RHIMEQ9AGP0, TSOXG_ARTSPQ46338, TSOXG_CORS1
Q50LE9, TSOXG_CORS9

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.5.3.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.5.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.-.-.-