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ENZYME

ENZYME entry: EC 1.5.3.26

Accepted Name
fructosyl amine oxidase (fructosamine-forming)
Reaction catalysed
an N-(1-deoxy-D-fructos-1-yl)amine + O2 + H2O <=> (1-deoxy-D-fructos-1-yl)amine + an aldehyde + H2O2
Comment(s)
  • Reducing sugars such as glucose react with amino groups in proteins via the spontaeous Maillard reaction, forming an unstable product that undergoes spontaneous rearrangement to a keto amine compound.
  • These reactions are known as glycation reactions, and the stable products are known as Amadori products.
  • This enzyme, characterized from a Pseudomonas sp. strain, cleaves the Amadori products at the alkylamine bond.
  • All other known fructosyl amine oxidases cleave the ketoamine bond (cf. EC 1.5.3.25).
Cross-references
BRENDA1.5.3.26
EC2PDB1.5.3.26
ExplorEnz1.5.3.26
PRIAM enzyme-specific profiles1.5.3.26
KEGG Ligand Database for Enzyme Nomenclature1.5.3.26
IUBMB Enzyme Nomenclature1.5.3.26
IntEnz1.5.3.26
MEDLINEFind literature relating to 1.5.3.26
MetaCyc1.5.3.26
Rhea expert-curated reactions1.5.3.26

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.5.3.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.5.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.-.-.-