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ENZYME

ENZYME entry: EC 1.5.5.2

Accepted Name
proline dehydrogenase
Reaction catalysed
a quinone + L-proline <=> (S)-1-pyrroline-5-carboxylate + a quinol + H(+)
Comment(s)
  • The electrons from L-proline are transferred to the FAD cofactor, and from there to a quinone acceptor.
  • In many organisms, ranging from bacteria to mammals, proline is oxidized to glutamate in a two-step process involving this enzyme and EC 1.2.1.88.
  • Both activities are carried out by the same enzyme in enterobacteria.
  • Formerly EC 1.5.99.8.
Cross-references
BRENDA1.5.5.2
EC2PDB1.5.5.2
ExplorEnz1.5.5.2
PRIAM enzyme-specific profiles1.5.5.2
KEGG Ligand Database for Enzyme Nomenclature1.5.5.2
IUBMB Enzyme Nomenclature1.5.5.2
IntEnz1.5.5.2
MEDLINEFind literature relating to 1.5.5.2
MetaCyc1.5.5.2
Rhea expert-curated reactions1.5.5.2
UniProtKB/Swiss-Prot
A6QQ74, HYPDH_BOVINQ9UF12, HYPDH_HUMANQ8VCZ9, HYPDH_MOUSE
Q2V057, HYPDH_RATQ6PAY6, HYPDH_XENLAP92983, PROD1_ARATH
Q8RMG1, PROD1_BACNAO32179, PROD1_BACSUQ6NKX1, PROD2_ARATH
Q8L2I5, PROD2_BACNAP94390, PROD2_BACSUQ9RW55, PRODH_DEIRA
Q72IB8, PRODH_THET2Q148G5, PROD_BOVINO45228, PROD_CAEEL
Q86H28, PROD_DICDIQ04499, PROD_DROMEO43272, PROD_HUMAN
Q9WU79, PROD_MOUSEO74524, PROD_SCHPOP09368, PUT1_YEAST
P09546, PUTA_ECOLIO52485, PUTA_KLEAEP23725, PUTA_KLEPN
P95629, PUTA_RHIMLP10503, PUTA_SALTY

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