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ENZYME

ENZYME entry: EC 1.2.1.88

PURL: https://purl.expasy.org/enzyme/EC/1.2.1.88
Accepted Name
L-glutamate gamma-semialdehyde dehydrogenase
Alternative Name(s)
1-pyrroline-5-carboxylate dehydrogenase
Delta(1)-pyrroline-5-carboxylate dehydrogenase
pyrroline-5-carboxylate dehydrogenase
Reaction catalysed
L-glutamate 5-semialdehyde + NAD(+) + H2O = L-glutamate + NADH + 2 H(+)
Comment(s)
  • This enzyme catalyzes the irreversible oxidation of glutamate-gamma- semialdehyde to glutamate as part of the proline degradation pathway.
  • (S)-1-pyrroline-5-carboxylate, the product of the first enzyme of the pathway (EC 1.5.5.2) is in spontaneous equilibrium with its tautomer L-glutamate gamma-semialdehyde.
  • In many bacterial species, both activities are carried out by a single bifunctional enzyme.
  • The enzyme can also oxidize other 1-pyrrolines, e.g. 3-hydroxy-1- pyrroline-5-carboxylate is converted into 4-hydroxyglutamate and (R)- 1-pyrroline-5-carboxylate is converted into D-glutamate.
  • NADP(+) can also act as acceptor, but with lower activity.
  • Formerly EC 1.5.1.12.
Cross-references
BRENDA1.2.1.88
EC2PDB1.2.1.88
ExplorEnz1.2.1.88
KEGG Ligand Database for Enzyme Nomenclature1.2.1.88
IUBMB Enzyme Nomenclature1.2.1.88
MEDLINEFind literature relating to 1.2.1.88
MetaCyc1.2.1.88
Rhea expert-curated reactions1.2.1.88
UniProtKB/Swiss-Prot
Q8VZC3, AL121_ARATHA7YWE4, AL4A1_BOVINQ7SY23, AL4A1_DANRE
Q54RA2, AL4A1_DICDIP30038, AL4A1_HUMANQ8CHT0, AL4A1_MOUSE
P0C2X9, AL4A1_RATP78568, PUT2_AGABIQ9P8I0, PUT2_EMENI
O74766, PUT2_SCHPOP07275, PUT2_YEASTP09546, PUTA_ECOLI
O52485, PUTA_KLEAEP23725, PUTA_KLEPNP95629, PUTA_RHIML
P10503, PUTA_SALTYQ9K9B2, ROCA1_HALH5P94391, ROCA2_BACSU
Q9K5Z5, ROCA2_HALH5B7GFV3, ROCA_ANOFWC3PBP4, ROCA_BACAA
C3L546, ROCA_BACACA0R909, ROCA_BACAHQ81ZF8, ROCA_BACAN
B7JM99, ROCA_BACC0P62028, ROCA_BACC1B7IUW8, ROCA_BACC2
C1EV77, ROCA_BACC3B7H4V1, ROCA_BACC4B7HSW8, ROCA_BACC7
A7GKJ4, ROCA_BACCNB9J1L9, ROCA_BACCQQ81IP0, ROCA_BACCR
Q63GS0, ROCA_BACCZQ6HP91, ROCA_BACHKQ65NN2, ROCA_BACLD
A9VRG6, ROCA_BACMKA8F9T1, ROCA_BACP2P39634, ROCA_BACSU
Q5L3K8, ROCA_GEOKAC5D4J5, ROCA_GEOSWA4IJP9, ROCA_GEOTN
Q8ERF4, ROCA_OCEIHA7X6R7, ROCA_STAA1A6U4T5, ROCA_STAA2
Q2FDV3, ROCA_STAA3Q2FV67, ROCA_STAA8A5IVY0, ROCA_STAA9
Q2YWA6, ROCA_STAABQ5HCZ6, ROCA_STAACA6QK44, ROCA_STAAE
P63939, ROCA_STAAMP99076, ROCA_STAANQ6GDP4, ROCA_STAAR
Q6G6C0, ROCA_STAASA8Z3F5, ROCA_STAATQ8NUR2, ROCA_STAAW
Q5HL59, ROCA_STAEQQ8CN04, ROCA_STAESQ4L966, ROCA_STAHJ
Q4A0E7, ROCA_STAS1

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.2.1.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.2.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.-.-.-