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ENZYME entry: EC 1.2.1.88

Accepted Name
L-glutamate gamma-semialdehyde dehydrogenase.
Alternative Name(s)
1-pyrroline-5-carboxylate dehydrogenase.
Delta(1)-pyrroline-5-carboxylate dehydrogenase.
Pyrroline-5-carboxylate dehydrogenase.
Reaction catalysed
L-glutamate 5-semialdehyde + NAD(+) + H(2)O <=> L-glutamate + NADH
Comment(s)
  • This enzyme catalyzes the irreversible oxidation of glutamate-gamma- semialdehyde to glutamate as part of the proline degradation pathway.
  • (S)-1-pyrroline-5-carboxylate, the product of the first enzyme of the pathway (EC 1.5.5.2) is in spontaneous equilibrium with its tautomer L-glutamate gamma-semialdehyde.
  • In many bacterial species, both activities are carried out by a single bifunctional enzyme.
  • The enzyme can also oxidize other 1-pyrrolines, e.g. 3-hydroxy-1- pyrroline-5-carboxylate is converted into 4-hydroxyglutamate and (R)- 1-pyrroline-5-carboxylate is converted into D-glutamate.
  • NADP(+) can also act as acceptor, but with lower activity.
  • Formerly EC 1.5.1.12.
Cross-references
PROSITEPDOC00068
BRENDA1.2.1.88
EC2PDB1.2.1.88
ExplorEnz1.2.1.88
PRIAM enzyme-specific profiles1.2.1.88
KEGG Ligand Database for Enzyme Nomenclature1.2.1.88
IUBMB Enzyme Nomenclature1.2.1.88
IntEnz1.2.1.88
MEDLINEFind literature relating to 1.2.1.88
MetaCyc1.2.1.88
Rhea expert-curated reactions1.2.1.88
UniProtKB/Swiss-Prot
Q8VZC3, AL121_ARATH;  A7YWE4, AL4A1_BOVIN;  Q7SY23, AL4A1_DANRE;  
Q54RA2, AL4A1_DICDI;  P30038, AL4A1_HUMAN;  Q8CHT0, AL4A1_MOUSE;  
P0C2X9, AL4A1_RAT;  P78568, PUT2_AGABI;  Q9P8I0, PUT2_EMENI;  
O74766, PUT2_SCHPO;  P07275, PUT2_YEAST;  P09546, PUTA_ECOLI;  
O52485, PUTA_KLEAE;  P23725, PUTA_KLEPN;  P95629, PUTA_RHIML;  
P10503, PUTA_SALTY;  Q9K9B2, ROCA1_ALKHC;  Q9K5Z5, ROCA2_ALKHC;  
P94391, ROCA2_BACSU;  B7GFV3, ROCA_ANOFW;  C3PBP4, ROCA_BACAA;  
C3L546, ROCA_BACAC;  A0R909, ROCA_BACAH;  Q81ZF8, ROCA_BACAN;  
B7JM99, ROCA_BACC0;  P62028, ROCA_BACC1;  B7IUW8, ROCA_BACC2;  
C1EV77, ROCA_BACC3;  B7H4V1, ROCA_BACC4;  B7HSW8, ROCA_BACC7;  
A7GKJ4, ROCA_BACCN;  B9J1L9, ROCA_BACCQ;  Q81IP0, ROCA_BACCR;  
Q63GS0, ROCA_BACCZ;  Q6HP91, ROCA_BACHK;  Q65NN2, ROCA_BACLD;  
A9VRG6, ROCA_BACMK;  A8F9T1, ROCA_BACP2;  P39634, ROCA_BACSU;  
Q5L3K8, ROCA_GEOKA;  C5D4J5, ROCA_GEOSW;  A4IJP9, ROCA_GEOTN;  
Q8ERF4, ROCA_OCEIH;  A7X6R7, ROCA_STAA1;  A6U4T5, ROCA_STAA2;  
Q2FDV3, ROCA_STAA3;  Q2FV67, ROCA_STAA8;  A5IVY0, ROCA_STAA9;  
Q2YWA6, ROCA_STAAB;  Q5HCZ6, ROCA_STAAC;  A6QK44, ROCA_STAAE;  
P63939, ROCA_STAAM;  P99076, ROCA_STAAN;  Q6GDP4, ROCA_STAAR;  
Q6G6C0, ROCA_STAAS;  A8Z3F5, ROCA_STAAT;  Q8NUR2, ROCA_STAAW;  
Q5HL59, ROCA_STAEQ;  Q8CN04, ROCA_STAES;  Q4L966, ROCA_STAHJ;  
Q4A0E7, ROCA_STAS1;  

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